| 神经生长因子凝胶抗炎抑菌作用初探 |
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| 引用本文： | 顾鹏毅,孙晋民,詹丽芬,关福兰,王毓平,贾兰玲,刘海军,陈相,郝文学. 神经生长因子凝胶抗炎抑菌作用初探[J]. 实用药物与临床, 2008, 11(6) |
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| 作者姓名： | 顾鹏毅 孙晋民 詹丽芬 关福兰 王毓平 贾兰玲 刘海军 陈相 郝文学 |
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| 作者单位： | 中国医科大学,实验技术中心一部,沈阳,110001;中国医科大学,药理学教研室,沈阳,110001;中国医科大学,肿瘤研究所,沈阳,110001;中国医科大学,93期,沈阳,110001;中国医科大学,老年病防治中心,沈阳,110001 |
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| 摘 要： | 目的观察神经生长因子(Nerve growth factor,NGF)凝胶剂的抗炎抑菌作用。方法以2,4-二硝基氟苯(DNFB)所致小鼠耳廓肿胀法研究抗炎作用;以稀释法研究NGF凝胶的体外抑菌作用。结果NGF凝胶有明显的抑制炎症模型小鼠耳廓肿胀的作用。对金黄色葡萄球菌(ATCC25923)、大肠埃希菌(ATCC25922)、铜绿假单胞菌(ATCC27853)、乙型溶血性链球菌(ATCC32210)有良好的抑菌作用。结论NGF凝胶具有良好的抗炎抑菌作用。
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| 关 键 词： | NGF凝胶剂 抗炎 抑菌 |
Study on the anti-inflammatory and antibacterial effects of nerve growth factor gel |
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| GU Peng-yi a,SUN Jin-min a,ZHAN Li-fen b,et al. Study on the anti-inflammatory and antibacterial effects of nerve growth factor gel[J]. Practical Pharmacy and Clinical Remedies, 2008, 11(6) |
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| Authors: | GU Peng-yi a SUN Jin-min a ZHAN Li-fen b et al |
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| Abstract: | Objective To study the antibacterial and anti-inflammatory effects of NGF gel.Methods The auricular swelling test of mice was used to study the anti-inflammatory effect.Diluting method was used to carry out laboratory observation on its bacteriostasis effects.Results NGF gel could depress swelling of mice in auricular swelling test,the water soluble fraction from NGF gel had a good antibacterial activity on Staphylococcus aureus(ATCC25923),Bacterium coli(ATCC29922),Pseudomonas aeruginosa(ATCC27853) and beta-hemolytic streptococci(ATCC32210).Conclusion NGF gel had a good anti-inflammatory and anti-bacterial activity. |
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| Keywords: | NGF gel Anti-inflammatory Antibacterial |
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