慢性阻塞性肺疾病继发肺部真菌感染的临床分析

目的　探讨老年慢性阻塞性肺疾病 (COPD)患者继发肺部真菌感染的致病因素。方法　回顾性分析 6 6例COPD患者的临床资料 ,其中 16例继发肺部真菌感染。结果　COPD继发肺部真菌感染的临床表现缺乏特异性 ,容易漏诊。病原菌以白色念珠菌为主。广谱联合应用抗生素 ,糖皮质激素的应用 ,营养不良 ,呼吸机辅助通气 ,高龄是继发真菌感染的主要诱因。结论　合理使用抗生素及糖皮质激素 ,预防医源性感染 ,增加患者免疫力 ,是降低COPD继发真菌感染的有效途径

Analysis of secondary pulmonary fungus infection of chronic obstructive pulmonary disease

Objective To explore the multi-factors related to secondary fungus infection in chronic obstructive pulmonary disease (COPD).Methods The clinical data of 16 COPD cases with secondary fungus infection were analyzed.Results The clinical manifestation of secondary fungus infection of COPD was not specific.Candida albicans (75%) was the most important pathogen.The main inducing factors of secondary pulmonary fungus infection of COPD included the combined use of broad spectrum antibiotics,use of corticosteroids,assisted ventilation,old age and hypoproteinemia.Conclusion To reduce the incidence of secondary pulmonary fungus infection in COPD,abuse of broad spectrum antibiotics and corticosteroids must be avoided,iatrogenic infection be prevented,the immunity of patients be enhanced.