金甲王颗粒对吗啡依赖猴和大鼠戒断症状的抑制作用

目的 :观察中药金甲王颗粒对吗啡依赖猴和大鼠戒断症状的抑制作用。方法 :采用吗啡依赖大鼠纳洛酮催促戒断、自然戒断模型以及吗啡依赖猴模型 ,观察金甲王颗粒对戒断症状的抑制作用。结果 :(1) 3个剂量的金甲王颗粒 (3 5 4、7 0 3和 14 0 7g生药·kg- 1 )均可显著降低吗啡依赖大鼠的催促戒断症状分值 (P <0 0 1) ;(2 )金甲王颗粒治疗组在大鼠自然戒断后期的体重恢复优于吗啡依赖组 ,3 5 4g生药·kg- 1 剂量的金甲王颗粒组大鼠体重下降百分率低于吗啡依赖组 ,但无统计学意义 (P >0 0 5 ) ;(3)在猴自然戒断治疗实验中 ,金甲王颗粒 3个剂量 (3 2 4、6 4 7、12 94g生药·kg- 1 )均能明显抑制吗啡依赖性猴的戒断症状 (P <0 0 5 ,P <0 0 1) ,金甲王颗粒中、大剂量组可明显抑制猴戒断后的体重下降 (P <0 0 5 ) ,但对体温下降的抑制作用不明显 (P >0 0 5 )。结论 :金甲王颗粒能改善吗啡依赖性动物催促戒断和自然戒断后所产生的戒断症状。

EFFECTS OF JINJIAWANG ON WITHDRAWAL SYNDROME IN MORPHINE-DEPENDENT MONKEYS AND RATS

Objective: To evaluate the effica cy of Jinjiawang on withdrawal syndromes of morphine dependent animals. Methods: Morphine dependent animal models were set up, including naloxo ne precipitated withdrawal of rats and natural withdrawal of monkeys and rats, t o observe the inhibitory effect of Jinjiawang on withdrawal syndromes. Results: (1)Jinjiawang(3.54, 7.03 and 14.07 g·kg -1) signifi cantly decreased the scores of withdrawal syndromes precipitated by naloxone ( P<0.01); (2) Compared with morphine group, Jinjiawang could improve weight re co very of rats on the later days of natural withdrawal; (3)Administrating Jinjiawa ng of various doses (3.24, 6.47 and 12.94 g·kg -1) for 7 days, the wit hdrawal syndromes of morphine dependent monkeys were inhibited(P<0.05, P <0.01). Both Jinjiawang 6.47 g·kg -1 and 12.94 g·kg -1 could si gn ificantly inhibit the weight loss induced by natural withdrawal. The inhibitory effects of Jinjiawang on body temperature were not significant (P>0.05). Conclusion: Jinjiawang can effectively inhibit the withdrawal s yndromes in morphine dependent monkeys and rats, showing significant detoxificat ion therapeutic effects.