| 超声波优化栀子苷提取的工艺研究 |
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| 引用本文： | 欧阳薇,乐龙,王志祥,张轻轻,党蓓蕾.超声波优化栀子苷提取的工艺研究[J].中国药物警戒,2011,8(3):154-157. |
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| 作者姓名： | 欧阳薇 乐龙 王志祥 张轻轻 党蓓蕾 |
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| 作者单位： | 中国药科大学制药工程教研室,江苏,南京,210009 |
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| 摘 要： | 目的 研究栀子苷的最佳超声提取条件.方法 采用响应面分析法优化栀子苷的超声提取条件,在单因素实验基础上利用BBD组合设计Box-Behnken中心组合设计拟合试验条件.结果 以栀子苷提取率为响应值进行多元二次响应回归分析,可得超声提取栀子苷的最佳工艺条件为:超声功率750.87 W、提取时间46.57 min,溶剂浓度52.06%、溶剂体积(料液比)1:64.09g·mL-1.此最优条件下栀子苷提取率预测为36.16 mg·g-1,验证值为35.49 mg·g-1,与预测值的相对误差为1.85%.结论 此最优工艺条件具有一定的实际应用价值,对工业化生产有一定的指导意义.
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| 关 键 词： | 栀子苷 超声提取 响应曲面分析法 |
Optimization of Ultrasonic Extraction Conditions of Geniposide |
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| OUYANG Wei,YUE Long,WANG Zhi-xiang,ZHANG Qing-ging,DANG Bei-lei.Optimization of Ultrasonic Extraction Conditions of Geniposide[J].Chinese JOurnal of Pharmacovigilance,2011,8(3):154-157. |
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| Authors: | OUYANG Wei YUE Long WANG Zhi-xiang ZHANG Qing-ging DANG Bei-lei |
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| Institution: | OUYANG Wei YUE Long WANG Zhi-xiang ZHANG Qing-qing DANG Bei-lei(Dept.of Pharmaceutical Engineering,China Pharmaceutical University,Jiangsu Nanjing 210009) |
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| Abstract: | Objective To study the technology of extracting geniposide from Gardenia jasminoides Ellis by ultrasound extraction.Methods Based on the single-factor experiments,a four-factor-three-level experiment design was developed by Box-Behnken central composite design method.Multi-quadratic equation was established with the yield of geniposide as response values.Results The optimum extraction condition was obtained as follows: ultrasound power 750.87 W,extraction time 46.57 min,ethanol concentration 52.06 % and eth... |
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| Keywords: | geniposide ultrasound extraction response surface methodology |
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