基于功效和物质基础的半夏毒性研究进展

目的为进行功效和毒性导向下的化学成分分离、控制和功效与毒性成分的＂量效关系＂和＂量毒关系＂研究提供文献依据和研究思路。方法对半夏近十几年来国内外相关文献进行整理、分析与归纳。结果半夏针对功效、物质基础和毒性的研究都局限在单一学科之间,缺乏两者之间甚至相互间的关联性研究。结论只有在半夏功效表达和功效物质基础分离与控制的过程中,进行毒性的研究和毒性物质基础的安全控制,才能提出切合半夏临床使用过程中不良反应预警方案和早期诊疗措施,保证半夏临床用药安全。

Research Development on Toxicity of Rhizoma Pinelliae Related to Efficacy and Chemical Material Basis

Objective To provide literature evidences asis composition of guided separation,control and efficacy, and research ideas of efficacy and toxicity of the chemical and the research on the ＂dose-effect relationship＂ and ＂dose-toxicity relationship＂ about the toxicial components. Methods References in the last decades both at home and abroad about Rhizoma Pinelliae were collated, analyzed and summarized. Results The research on Rhizoma Pinelliae about the toxicial effects based on the efficacy and the material basis are confined to single disciplines. Between and even mutual relevance studies are very lack of. Conclusion The research on Rhizoma Pinelliae about the toxicity and margin of safety control based on the chemical separation and quality control about the effective material basis combined with the process of the effectiveness of expression, so as to provide consummating safety standards and putting forward early-warning scheme of adverse reaction, the early diagnosis and treatment measures that can be referred to clinical usage. Rhizoma Pinellia will be ensured to use safety as a clinical drug.