辛夷酯素抗过敏作用机理探讨

目的探讨辛夷酯素抗过敏作用机理，为指导抗过敏药物的研发及指导I临床用药提供参考及思路。方法分别用形态法和荧光法观察辛夷酯素药物血清冻干粉对致敏大鼠腹腔肥大细胞（PMC）脱颗粒和组织胺释放的影响，研究辛夷酯素的抗过敏作用，探讨抗过敏机制。结果给药15rain、60rain后，制备的药物血清冻干粉对PMC脱颗粒和组织胺释放有明显的抑制作用，且存在一定的时效关系。其抗过敏的机理可能与其稳定肥大细胞细胞膜，抑制其脱颗粒和释放过敏介质有关。结论辛夷酯素对过敏症状有明显的抑制作用，其抗过敏机制与抑制PMC释放过敏性介质组织胺有关。

The Study on Antiallergenic Mechanisms of Effective Parts from Flos Magnoliae

Objective The antiallergenic mechanisms of effective parts from Flos Magnoliae were studied, so as to provide references and research ideas for antiallergenic drugs and innovative drugs. Methods The effect of sensitized rat peritoneal mast cells（PMC） degranulation and the release of histamine about Flos Magnoliae effective parts of the freeze-dried powder of serum drug were observed through the patterns and fluorescence, the antiallergenic effects of Flos Magnoliae was researched and the antiallergenic mechanisms was studied. Results The PMC degranulation and the release of histamine were significantly inhibited after given the preparation of freeze-dried powder of serum drug 15 and 60min, and there are some limitations relations. The antiallergenic mechanisms of F1os Magno//ae may be related to the mast cell membrane stability, inhibiting their degranulation and the release of allergic media. Conclusion The effective parts of Flos Magnoliae has an significant effect, and there are some relations about Flos Magnoh＇ae effective antiallergenic parts and the release of allergic PMC medium-the histamine.