| 伊立替康联合替吉奥方案化疗致严重迟发性腹泻1例分析 |
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| 引用本文： | 梅丹,陆俊国,顾海娟,倪美鑫.伊立替康联合替吉奥方案化疗致严重迟发性腹泻1例分析[J].中国药物警戒,2020(6):373-376. |
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| 作者姓名： | 梅丹 陆俊国 顾海娟 倪美鑫 |
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| 作者单位： | 江苏省南通市肿瘤医院 |
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| 基金项目： | 南通市卫健委科研课题(QA2019026):β-葡萄糖醛酸苷酶与C-反应蛋白在预测伊立替康致迟发性腹泻中的作用;南通市科技局科技计划(指导性)项目(MSZ18247)/南通市药学会-常州四药医院药学基金科研项目(ntyx1809):血药浓度监测优化吉非替尼治疗EGFR突变的晚期非小细胞肺癌的研究。 |
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| 摘 要： | 目的分析伊立替康联合替吉奥方案化疗致1例尿苷二磷酸葡萄糖醛酸转移酶1A1野生型患者严重迟发性腹泻。方法分析该患者接受伊立替康联合替吉奥方案化疗后发生迟发性腹泻的诊疗过程并进行文献印证。结果严重迟发性腹泻可能由伊立替康联合替吉奥方案化疗所致,与患者体内伊立替康转运体的基因多态性、联合使用替吉奥等相关。结论尿苷二磷酸葡萄糖醛酸转移酶1A1野生型患者使用伊立替康联合替吉奥方案化疗时不能忽视严重迟发性腹泻发生的可能。
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| 关 键 词： | 迟发性腹泻 伊立替康联合替吉奥方案 UGT1A1基因多态性 |
Serious Delayed Diarrhea Induced by IRIS Regimen in an UGT1A1-wild-genotype Patient |
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| MEI Dan,LU Junguo,GU Haijuan,NI Meixin.Serious Delayed Diarrhea Induced by IRIS Regimen in an UGT1A1-wild-genotype Patient[J].Chinese JOurnal of Pharmacovigilance,2020(6):373-376. |
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| Authors: | MEI Dan LU Junguo GU Haijuan NI Meixin |
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| Institution: | (Affiliated Tumor Hospital of Nantong University,Nantong Jiangsu 226361,China) |
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| Abstract: | Objective To report and analyze one case of serious delayed diarrhea induced by chemotherapy of irinotecan combined with S-1(IRIS regimen)in an uridine-diphosphoglucuronosyl transferase 1A1(UGT1A1)-wild-genotype patient with metastatic recal cancer.Methods The diagnosis and treatment process of the case of delayed diarrhea after IRIS regimen chemotherapy was analyzed and related literature was reviewed.Results The serious delayed diarrhea was possibly induced by IRIS regimen chemotherapy,which might be related to the gene polymorphisms of irinotecan transporters and the combination with S-1.Conclusion We should be alert to the occurrence of serious delayed diarrhea when IRIS regimen chemotherapy is used for UGT1A1-wild-genotype patients. |
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| Keywords: | Delayed diarrhea IRIS regimen UGT1A1 gene polymorphisms |
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