从药动学/药效学角度优化头孢哌酮/舒巴坦的临床给药方案

摘要：头孢哌酮/舒巴坦是目前临床广泛使用的一种β-内酰胺类合剂。该药抗菌谱广，主要用于治疗呼吸道感染、腹腔感 染等多种感染。该药临床已使用多年，对于耐药菌的治疗地位也越来越受到广泛关注。故综述其药动学/药效学特点，总结文献 报道的给药方案优化策略，以供临床使用中借鉴和参考。

Pharmacokinetics/pharmacodynamics mediated dose optimization of cefoperazone/sulbactam in clinics

Abstract Cefoperazone/sulbactam is a combination of β-lactam antibiotic with β-lactamase inhibitor. It is widely used in the treatment of respiratory tract infection, abdominal infection, and other infections. The pharmacokinetics/pharmacodynamics and the dosing optimization strategies of cefoperazone/sulbactam compound were reviewed.