头孢洛扎硫酸盐制备方法的改进

将起始原料ACLE·HCl首先与7-位侧链噻二唑化合物TATD反应，然后再与吡唑化合物UBT进行反应，并用三氟乙酸进行脱保护基反应。最后经过纯化析晶，合成头孢洛扎硫酸盐。该工艺得到头孢洛扎硫酸盐的纯度高，原料易得，纯化时不需要过柱，更适合工业化生产。

The improvement of the preparation of ceftolozane sulfate

The starting material ACLE·HCl was reacted with the thiadiazole moiety (7-side chain) TATD, subsequently the pyrazole moiety UBT was introduced and the global deprotection was accomplished with trifluoroacetic acid. Finally, ceftolozane sulfate was synthesized after purification and crystallization. The ceftolozane sulfate in high purity was prepared via the process which comprised no columns during purification for the final product. Furthermore, the raw materials of this process were easy to obtain. The process could thus easily be scaled up to an industrial