| 多黏菌素抗菌机理及耐药机制研究进展 |
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| 引用本文： | 乔涵,游雪甫,李聪然.多黏菌素抗菌机理及耐药机制研究进展[J].中国抗生素杂志,2019,44(7):770-777. |
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| 作者姓名： | 乔涵 游雪甫 李聪然 |
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| 作者单位： | 中国医学科学院北京协和医学院医药生物技术研究所抗感染药物研究北京市重点实验室 |
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| 基金项目： | 中国医学科学院协同创新团队项目(No.2016-I2M-3-014) |
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| 摘 要： | 多黏菌素是临床治疗多重耐药的革兰阴性菌感染的最后一道防线。但随着多黏菌素在临床、畜牧业及农业上使用的逐年增加以及一些抗生素滥用情况的发生,导致其对革兰阴性菌的治疗效果相对下降,出现了多种多黏菌素耐药的革兰阴性菌。本文就多黏菌素的抗菌机理、副作用机制、对不同耐药菌的耐药机制进行综述。
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| 关 键 词： | 革兰阴性菌 多黏菌素耐药 mcr-1 耐药机制 副作用机制 |
Advances on mechanisms of action and resistance of polymyxins |
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| Qiao Han,You Xue-fu,Li Cong-ran.Advances on mechanisms of action and resistance of polymyxins[J].Chinese Journal of Antibiotics,2019,44(7):770-777. |
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| Authors: | Qiao Han You Xue-fu Li Cong-ran |
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| Institution: | (Beijing Key Laboratory of Antimicrobial Agents, Institute of Medicinal Biotechnology, Peking Union Medical College, ChineseAcademy of Medical Sciences, Beijing 100050) |
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| Abstract: | Polymyxins are the last line of defense in the treatment of multidrug resistant Gram-negative bacterial infections. However, as the use of polymyxins in medical clinics, animal husbandry, and agriculture increased year by year, and the abuse of some antibiotics, the therapeutic efficacy of polymyxins on Gram-negative bacteria was gradually reduced, and many polymyxin resistant Gram-negative isolates emerged. This article reviews the mechanisms of action, resistance, and adverse effects of |
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| Keywords: | Gram-negative bacteria Polymyxin resistance mcr-1 Drug resistance mechanisms Side effect mechanisms |
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