| Hsp90抑制剂的研究进展 |
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| 引用本文： | 孟帅,山广志,李卓荣.Hsp90抑制剂的研究进展[J].中国抗生素杂志,2011,36(4). |
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| 作者姓名： | 孟帅 山广志 李卓荣 |
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| 作者单位： | 中国医学科学院北京协和医学院医药生物技术研究所,北京,100050 |
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| 基金项目： | "863"计划课题项目，重大新药创制重大专项 |
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| 摘 要： | 热休克蛋白90(Hsp90)是生物进化过程中高度保守的一类蛋白,作为分子伴侣对细胞中众多信号蛋白的构象成熟和功能稳定进行调控.近年来的研究证明,Hsp90与肿瘤发生、发展、生物学行为及其预后有密切的关系,已成为新兴的抗肿瘤药物作用靶点,众多Hsp90抑制剂应运而生,同时基于结构的小分子抑制剂的设计也引起日益广泛的关注,本文就Hsp90的结构特点及其相关抑制剂进行综述,以期对Hsp90抑制剂的发现和优化提供依据.
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| 关 键 词： | 抑制剂 基于结构的药物设计 |
Recent progress in the study of Hsp90 inhibitors |
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| Meng Shuai,Shan Guang-zhi,Li Zhuo-rong.Recent progress in the study of Hsp90 inhibitors[J].Chinese Journal of Antibiotics,2011,36(4). |
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| Authors: | Meng Shuai Shan Guang-zhi Li Zhuo-rong |
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| Institution: | Meng Shuai,Shan Guang-zhi and Li Zhuo-rong(Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 10050) |
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| Abstract: | Heat shock protein 90(Hsp90) is a highly conserved chaperone that is responsible for the maturation and activity of a variety of signaling proteins.Hsp90 has become the target of antitumor drugs because of its close relationship with occurrence and development,biological behavior and prognosis of tumor.Many Hsp90 inhibitors have emerged,and interests have arisen around structure-based design of small molecules.In this review,we illustrate the structure features and related inhibitors aiming at discovering a... |
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| Keywords: | Hsp90 |
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