海洋来源真菌A-f-11中吲哚二酮哌嗪类抗肿瘤活性成分的研究

对海洋来源具有抗肿瘤活性的真菌A-f-11中活性次级代谢产物进行了研究．采用活性追踪的方法从乙酸乙酯提取物中分离得到7个含吲哚基的二酮哌嗪类化合物，根据化合物的光谱特征和理化性质分别鉴定为cyclo—L—tryptophyl-L—proline（1），N—Prenyl—cyclo—L—tryptophyl—L—proline（2），tryprostatln B（3），demethoxyfumltremorgin C（4），fumitremorgin C（5），cyclotryprostatins B（6）和fumitremorgin B（7），其中化合物2为新天然产物。利用丽丝胺罗丹明法，对7个单体化合物的抗肿瘤活性进行了初步评价。

Studies on the indolyl diketopiperazine analogs produced by marine-derived fungus A-f-11

To investigate the antitumor secondary metabolites of marine-derived fungal A-f-11. Seven indolyl diketopiperazine compounds were isolated with bioassay-guided separation procedure. The structures of these compounds were determined through extensive analysis of 1D and 2D-NMR data. Their antitumor activities against K562 cell lines were preliminarily evaluated by the lissamine rhodamine B method. Compound 2 was a new natural product.