| 海洋新放线菌及其次级代谢产物研究进展 |
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| 引用本文： | 王淑霞,朱天骄,卢圳域,顾谦群,朱伟明.海洋新放线菌及其次级代谢产物研究进展[J].中国抗生素杂志,2007,32(9):513-519. |
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| 作者姓名： | 王淑霞 朱天骄 卢圳域 顾谦群 朱伟明 |
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| 作者单位： | 教育部海洋药物重点实验室,山东省海洋药物重点实验室,中国海洋大学医药学院,青岛266003 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 由于自身特殊的生存环境,海洋放线菌具有复杂独特的代谢途径,产生了诸多结构新颖、生物活性显著的次级代谢产物,这些活性代谢产物为新抗生素的发现提供了丰富的先导化合物,有些已经进入临床前研究。本文简要介绍近十几年从海洋样品中分离到的放线菌新种属及其次级代谢产物研究概况。
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| 关 键 词： | 海洋放线菌 代谢产物 |
| 文章编号： | 1001-8689（2007）09-0513-07 |
| 修稿时间： | 2007-01-04 |
Recent progress in the discovery of new marine-derived actinomycetes and their secondary metabolites |
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| Wang Shu-xia,Zhu Tian-jiao,Lu Zhen-yu,Gu Qian-qun,Zhu Wei-ming.Recent progress in the discovery of new marine-derived actinomycetes and their secondary metabolites[J].Chinese Journal of Antibiotics,2007,32(9):513-519. |
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| Authors: | Wang Shu-xia Zhu Tian-jiao Lu Zhen-yu Gu Qian-qun Zhu Wei-ming |
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| Institution: | Key Laboratory of Marine Drugs of Ministry of Education, China, Key Laboratory of Marine School of Medicine and Pharmacy, Ocean University of China, Qingdao Zhu Wei-ming Drugs of Shandong Province, 266003 |
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| Abstract: | Due to the special living environment,marine-derived actinomycetes possess distinct and complex metabolic capabilities,resulting in wide diversity of their secondary metabolites in chemical structure and biological activity.Among them,many valuable leading compounds were obtained for discovery of new antibiotics,and some had been selected for preclinical study.The research advances in discovery of new actinomycetes and their secondary metabolites were briefly reviewed in this paper. |
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| Keywords: | Salinispora Verrucosispora Marinispora |
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