| 第二代糖肽类抗生素的研究进展 |
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| 引用本文： | 尚新艳,阮丽军,许激扬,陈代杰.第二代糖肽类抗生素的研究进展[J].中国抗生素杂志,2007,32(5):263-267,312. |
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| 作者姓名： | 尚新艳 阮丽军 许激扬 陈代杰 |
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| 作者单位： | 1. 中国药科大学生命科学与技术学院,南京,210009
2. 上海医药工业研究院,上海,200040;上海来益生物药物研究开发中心,上海,201203 |
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| 摘 要： | 随着细菌耐药的不断升级，耐万古霉素肠球菌、高度耐糖肽类抗生素的金葡菌的出现，给临床抗感染治疗带来极大困难。开发新型糖肽类抗生素刻不容缓。人们对万古霉素等天然糖肽类抗生素进行化学修饰，得到了一系列有价值的衍生物，其中oritavancin、dalbavancin和telavancin已进入Ⅲ期临床和新药注册。本文对第二代糖肽类抗生素的结构特征、药效学与药动学特征以及临床应用作一综述。
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| 关 键 词： | 第二代糖肽类抗生紊 |
| 文章编号： | 1001-8689（2007）05-0263-05 |
| 修稿时间： | 2006-03-142006-07-12 |
Advance of research on the second generation of glycopeptide antibiotics |
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| Shang Xin-yan,Ruan Li-jun,Xu Ji-yang,Chen Dai-jie.Advance of research on the second generation of glycopeptide antibiotics[J].Chinese Journal of Antibiotics,2007,32(5):263-267,312. |
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| Authors: | Shang Xin-yan Ruan Li-jun Xu Ji-yang Chen Dai-jie |
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| Abstract: | Development of resistance to antibacterial agents,especially the advent of vancomycin-resistant Enterococcus(VRE) and glycopeptide-resistant Staphylococcus aureus(GRSA) is a mounting problem that continues to compromise the clinical effectiveness of anti-infectious drugs.It is essential to develop new glycopeptide antibiotics.Three of these new derivatives obtained by semi-synthesis starting from natural compounds,are now in clinical development(oritavancin and telavancin,as derivatives of vancomycin;and dalbavancin,as a derivative of teicoplanin).The review focuses on the structures,pharmacokinetic and pharmacodynamic parameters and the clinical research status related to the second-generation glycopeptide antibiotics. |
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| Keywords: | Oritavancin Dalbavancin Telavancin |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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