| 国产亚胺培南／西司他丁的体内抗菌活性研究 |
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| 引用本文： | 娄人慧,游雪甫.国产亚胺培南／西司他丁的体内抗菌活性研究[J].中国抗生素杂志,1997,22(3):198-200. |
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| 作者姓名： | 娄人慧 游雪甫 |
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| 作者单位： | 协和医科大学，中国医学科学院医药生物技术研究所 |
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| 基金项目： | 八五”国家科技攻关计划资助 |
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| 摘 要： | 皮下注射国产亚胺培南／西司他丁对金葡球菌、大肠杆菌、铜绿假单胞菌各２株感染小鼠的ＥＤ５０分别为０．０７７和０．０６９ｍｇ／ｋｇ、０．６３３和１．１６９ｍｇ／ｋｇ、０．７３４和０．６４４ｍｇ／ｋｇ，与进口亚胺培南／西司他丁的ＥＤ５０（０．０６９和０．０７３ｍｇ／ｋｇ、０．６７０和１．２９８ｍｇ／ｋｇ、０．６２８和０．６５５ｍｇ／ｋｇ）相近，国产与进口亚胺培南／西司他丁的ＥＤ５０经统计学处理无显著性差异（Ｐ＞０．０５）。
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| 关 键 词： | 亚胺培南／西司他丁 ED_（50） |
Study on antibacterial activity of imipenem/cilastatin in vivo |
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| Lou Renhui,You Xuefu,Zhang Weixin,Yan Guihua and Chen Huizhen.Study on antibacterial activity of imipenem/cilastatin in vivo[J].Chinese Journal of Antibiotics,1997,22(3):198-200. |
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| Authors: | Lou Renhui You Xuefu Zhang Weixin Yan Guihua and Chen Huizhen |
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| Abstract: | Imipenem/cilastatin has excellent therapeutic efficacy against intraperitoneal infection with 2 strains each of S.aureu, E.coli and Ps.aeruginosa in mice by subcutaneous injection. The ED 50 s of domestic imipenem/cilastatin were 0.077 and 0.069 mg/kg against S.aureus 15 and 44; 0.063 and 1.169mg/kg against E.coli 1515 and 288; 0.734 and 0.644mg/kg against Ps.aeruginosa 29 and 17, respectively, which are similar to those of imported imipenem/cilastatin (0.069 and 0.073mg/kg against S.aureus 15 and 44; 0.670 and 1.298mg/kg against E.coli 1515 and 288; 0.628 and 0.655mg/kg against Ps.aeruginosa 29 and 17). The ED 50 s of both drugs show no signicant differences after statistical treatment ( P >0.05). |
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| Keywords: | Imipenem/cilastatin ED 50 |
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