动态血压监测评价替米沙坦的降压效果

目的以24h动态血压监测评价替米沙坦治疗轻、中度原发性高血压患者的疗效。方法选择30例轻中度高血压患者,予以替米沙坦80mg/d治疗8周,分别于治疗前后行24h动态血压监测并计算其谷峰比值、平滑指数后进行比较分析。结果治疗8周后24h平均收缩压、舒张压;日间平均收缩压、舒张压;夜间平均收缩压、舒张压与治疗前比较均有显著性降低(P<0.01),收缩压、舒张压负荷也有显著降低(P<0.01)。收缩压谷峰比值为63.2%,舒张压谷峰比值65.8%,收缩压平滑指数为(1.08±0.34),舒张压平滑指数为(1.12±0.23)。结论替米沙坦具有良好的降压效果及满意的谷峰比值、平滑指数,临床应用安全。

Evaluation of Antihypertensive Effect of Compound Telmisartan on Essential Hypertension by Ambulatory Blood Pressure Monitoring

Objective To evaluate the antihypertensive effects of telmisartan in patients with mild-to-moderate essential hypertension by 24 hour ambulatory blood pressure monitoring.Methods Thirty patients with mild-to-moderate essential hypertension were treated with telmisartan 80mg,once a day for 8 weeks.24 h ambulatory blood pressure monitoring(ABPM) was performed before and atfter treatment,the trough/peak ratio and smoothness index were calculated.Results The mean systolic blood pressure(SBP) and diastolic blood...