| HPLC法同时测定复方雌二醇控释贴片中雌／孕激素的含量 |
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| 引用本文： | 王俏,叶金翠.HPLC法同时测定复方雌二醇控释贴片中雌／孕激素的含量[J].药物分析杂志,1999,19(4):244-246. |
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| 作者姓名： | 王俏 叶金翠 |
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| 作者单位： | 浙江省医学科学院药物研究所 |
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| 摘 要： | 目的：建立同时测定复方雌二醇透皮控释巾片中雌二醇（Ｅ２）和炔诺酮醋酸酯（ＮＥＴＡ）含量的反相ＨＰＬＣ法。方法：色谱柱为岛津柱（５μｍ，６．０ｍｍ＊１５０ｍｍ）检测波长为２８０ｍｍ（０－－８．５ｍｉｎ），２４０ｎｍ（８．５１－－１５ｍｉｎ）；流动相为甲醇－水（７５：２５）。结果：Ｅ２、ＮＥＴＡ线性范围分别为２．０～２０、６．０～６０ｍｇ．Ｌ^-1。平均回收率分别为１０１．０％（ＲＳＤ＝１．６％）、９９
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| 关 键 词： | HPLC法 炔诺酮醋酸酯 雌二醇 控释贴片 |
Determination of Compound Estradiol ControlledDelivery Patches by HPLC |
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| Wang Qiao,Ye Jincui and Chen Guoshen.Determination of Compound Estradiol ControlledDelivery Patches by HPLC[J].Chinese Journal of Pharmaceutical Analysis,1999,19(4):244-246. |
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| Authors: | Wang Qiao Ye Jincui and Chen Guoshen |
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| Abstract: | Objective: To develop a HPLC method for assaying estradiol(E2)and norethindrone acetate(NETA)in compound estradiol controlled delivery patches simultaneously Method: With Shim-pack CLC C18(5m)column(60 mm150 mm),methanol and water(7525)as mobile phase,detector set at 280nm(0850 min),240 nm(85115 min). Results: Linear ranges of E2 and NETA were 2020 mgL-1 and 6060 mgL-1,respectivelyThe average recovery rates(n=5)of E2 and NETA were 1010%(RSD=16%)and 997%(RSD=14%),respectively. Conclusion:This method provides a simple,rapid and accurate way to control the quality of compound estradiol controlled delivery patches |
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| Keywords: | HPLC estradiol norethindrone acetate compound estradiol controlled delivery patches |
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