| 喹诺酮药物荷移反应的研究 |
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| 引用本文： | 宋健玲,王仲英,宣春生,郭芬芳.喹诺酮药物荷移反应的研究[J].药物分析杂志,1999,19(3):167-170. |
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| 作者姓名： | 宋健玲 王仲英 宣春生 郭芬芳 |
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| 作者单位： | 太原理工大学应用化学系 |
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| 摘 要： | 目的：研究分光光度法测定吡哌酸、氟哌酸和乳酸环丙氟哌酸的含量，方法：基于在水溶液中药物与２，４二硝基酚生成荷移络合物。结果：表现摩尔吸光系数ε＝１３４×１０４～４２０×１０４Ｌ·ｍｏｌ－１·ｃｍ－１，络合物组成均为１∶１，络合物的最大吸收波长λｍａｘ＝３９７４～４０４０ｎｍ，相对标准偏差为１４３％～３６５％。结论：应用本方法测定吡哌酸、氟哌酸和乳酸环丙氟哌酸药物制剂含量可得到满意的结果。
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| 关 键 词： | 荷移络合物 分光光度法 抗菌素 2 4－二硝基酚 |
Study on Charge Transfer Reaction of Quinolones |
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| Song Jianling,Wang Zhongying,Xuan Chunsheng and Guo Fenfang.Study on Charge Transfer Reaction of Quinolones[J].Chinese Journal of Pharmaceutical Analysis,1999,19(3):167-170. |
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| Authors: | Song Jianling Wang Zhongying Xuan Chunsheng and Guo Fenfang |
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| Abstract: | Objective: A spectrophotometric method has been developed for the determination of pipemidic acid,norfloxacin and ciprofloxacin lactated. Method: It is based on a reaction of charge transfer with 2BF, 4dinitrophenol in the water medium. Results: Apparent molar absorptivities were 134104420104 Lmol-1cm-1.The composition of the charge transfer complex were 11.The maximum absorbent were 39744040 nm.The RSD were 14365%. Conclusion: The proposed method has been applied to the determination of pipemidic acid,norfloxacin and ciprofloxacin lactate in tablets with satisfactory results. |
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| Keywords: | charge transfer complex spectrophotometry antibacterial drug 2 4dinitrophenol |
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