前列地尔联合艾塞那肽对2型糖尿病的疗效

目的探讨前列地尔联合艾塞那肽对2型糖尿病患者的疗效及对血清脂肪特异性丝氨酸蛋白内抑制剂(vaspin)和内抑素(NES)的影响。方法选取130例糖尿病患者,随机均分为观察组和对照组,每组65例。对照组给予艾塞那肽治疗,观察组给予艾塞那肽联合前列地尔治疗,治疗2周后观察2组患者的生化功能、血管功能、肾功能及血清Vaspin和NES水平。结果治疗前2组患者的生化功能、血管功能、肾功能及血清vaspin和NES水平比较差异无统计学意义,治疗后2组患者的空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1C)、体质量指数(BMI)、空腹C肽、餐后2 h C肽、三酰甘油(TG)和总胆固醇(TC)均显著下降,观察组下降更显著(P<0.05);治疗后2组患者的尿总蛋白、尿素氮(BUN)和血肌酐(SCr)均显著下降,观察组下降更显著(P<0.05);治疗后2组患者的收缩期血管峰值血流速度(PSV)和内膜中层厚度(IMT)均降低,且观察组下降更显著,狭窄率均升高,且观察组升高更显著(P<0.05);治疗后2组患者的血清vaspin和NES水平均显著升高,且观察组升高更显著(P<0.05);2组患者均未出现严重的不良反应。结论前列地尔联合艾塞那肽治疗2型糖尿病患者的效果较好,可有效控制血糖,显著升高血清vaspin、NES水平,改善患者的血管功能、肾功能,降低糖尿病的并发症发生率。

Effect of alprostadil combined with exenatide on type 2 diabetes mellitus

Objective To investigate the effect of alprostadil combined with exenatide on serum fatty specific serine protein inhibitors(vaspin)and endostatin(NSE)in patients with type 2 diabetes mellitus.Methods 130 patients with type 2 diabetes were randomly selected and divided into observation group and control group,each group 65 cases.The control group was treated with exenatide,and the observation group was treated with exenatide combined with alprostadil.After 2 weeks of treatment,the biochemical function,vascular function,renal function,serum Vaspin and NSE levels of the 2 groups were observed.Results There was no significant difference in biochemical function,vascular function,renal function,serum Vaspin and NSE between the 2 groups before treatment.After treatment,the FBG,2 h PG,HbA1C,BMI,fasting C peptide,postprandial 2 h C peptide,TG,TC in the 2 groups decreased significantly,and the decrease in the observation group was more significant(P<0.05).The urinary total protein,BUN and SCr of the 2 groups decreased significantly,and the observation group decreased more significantly(P<0.05).The PSV and IMT in both group were reduced,and the observation group decreased more significantly,the stenosis rate increased,and the observation group increased more significantly(P<0.05).The levels of vaspin and NES in serum of the 2 groups increased significantly,and the observation group increased more significantly(P<0.05).No serious adverse reactions were found in all 2 groups.Conclusion The effect of alprostadil combined with exenatide in the treatment of type 2 diabetes is better.It can effectively control blood sugar,increase the level of serum vaspin and NES,improve the vascular function and renal function of the patients,and reduce the incidence of diabetes complications.