| 气相色谱法测定西黄胶囊中麝香酮的含量 |
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| 引用本文： | 王粉安,衷红梅,赵东玲.气相色谱法测定西黄胶囊中麝香酮的含量[J].西北药学杂志,2012,27(5):431-433. |
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| 作者姓名： | 王粉安 衷红梅 赵东玲 |
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| 作者单位： | 西安交大瑞鑫药业有限公司;陕西省药品检验所;西安交大医院 |
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| 摘 要： | 目的建立测定西黄胶囊中麝香酮的气相色谱法。方法色谱柱:OV-17毛细管柱(30.0m×0.32mm,1.0μm);初始柱温:150℃,保持26min;再以20℃.min-1的升温速率升至230℃,保持20min;进样口温度:200℃;检测器温度:250℃;载气:氮气;流速:2.0mL.min-1。结果回归方程线性关系良好,线性范围为1.5～299.2mg.L-1,平均回收率为94.7%,RSD1.3%。结论该方法准确、灵敏,能有效控制西黄胶囊的质量。
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| 关 键 词： | 西黄胶囊 麝香酮 含量测定 气相色谱法 |
Determination of the content of muscone in Xihuang Capsules by gas chromatography |
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| WANG Fenan,ZHONG Hongmei,ZHAO Dongling.Determination of the content of muscone in Xihuang Capsules by gas chromatography[J].Northwest Pharmaceutical Journal,2012,27(5):431-433. |
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| Authors: | WANG Fenan ZHONG Hongmei ZHAO Dongling |
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| Institution: | 1.Xi′an Jiaoda Ruixin Pharmaceutical Co.Ltd,Xi′an 710061,China;2.Shaanxi Institute for Food and Drug Control,Xi′an 710061,China;3.Hospital of Xi′an Jiaotong University,Xi′an 710061,China) |
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| Abstract: | Objective To establish a method for the determination of muscone in Xihuang Capsules.Methods A gas chromatography method was developed by using an OV-17 column(30.0 m×0.32 mm×1 μm),with inlets temperature at 200 ℃,FID detector,and temperature at 250 ℃.The initial temperature was kept at 150 ℃ for 26 min,raised to 230 ℃ at the rate of 20 ℃ and maintained 20 min.Result There was a linear relationship within the test range of 1.5~299.2 mg·L-1(r=0.999 8).The average recovery was 94.7% with RSD 1.3%.Conclusion The method was proved to be accurate and sensitive,and could be used for the drug quality control. |
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| Keywords: | Xihuang Capsules muscone gas chromatography content determination |
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