| 复方左氧氟沙星滴眼液的研制及临床应用 |
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| 引用本文： | 张雷,林艳,李中华,梁毅,陈涌江.复方左氧氟沙星滴眼液的研制及临床应用[J].中国药房,2003,14(6):341-343. |
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| 作者姓名： | 张雷 林艳 李中华 梁毅 陈涌江 |
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| 作者单位： | 解放军第465医院,吉林市,132013 |
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| 摘 要： | 目的 :研究复方左氧氟沙星滴眼液的制备及质量控制方法 ,并观察其临床疗效。方法 :以左氧氟沙星为主药配伍地塞米松磷酸钠 ,选择磷酸盐作为缓冲剂 ,依地酸二钠作为稳定剂 ,采用紫外分光光度法测定左氧氟沙星的含量。结果 :制剂稳定 ,左氧氟沙星在2～6μg/ml范围内线性关系良好 ;C=26 1780A—1 0838(r=0 9997) ;平均回收率为100 34 % ,RSD=0 44%(n=5)。结论 :制备工艺简单 ,质控方法可靠 ,疗效良好
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| 关 键 词： | 左氧氟沙星 滴眼液 质量控制 |
| 文章编号： | 1001-0408(2003)06-0341-03 |
| 修稿时间： | 2002年7月12日 |
Preparation and Clinical Application of Compound Levofloxacin Eye Drops |
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| ZHANG Lei,LIN Yan,LI Zhonghua,LIANG Yi,CHEN Yongjiang.Preparation and Clinical Application of Compound Levofloxacin Eye Drops[J].China Pharmacy,2003,14(6):341-343. |
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| Authors: | ZHANG Lei LIN Yan LI Zhonghua LIANG Yi CHEN Yongjiang |
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| Abstract: | OBJECTIVE:To study the preparation of compound levofloxacin eye drops and its quality control,then observe its clinical effect.METHODS:Levofloxacin was used as basic remedy mixed with dexamethasone sodium phosphate and phosˉphate was adoped as buffer,while EDTA-2Na as stabilizer.Finally the content of levofloxacin was determined by UV-specˉtrophotometric method.RESULTS:The preparations was stable and within the range of2～6μg/ml,the concentration of levˉofloxacin had a linear relationship with absorbance(C=26.1780A—1.0838,r=0.9997).The average rate of recovery was100.34%and RSD was0.44%(n=5).CONCLUSION:This preparation has a good effect with simple preparing technique and reliable quality control. |
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| Keywords: | levofloxacin eye drops quality control |
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