87例中药制剂不良反应报告分析

目的:分析中药制剂不良反应(ADR)的特点及影响因素,促进临床合理用药。方法:采用回归性分析方法,对我院2006年87例涉及中药制剂的ADR报告分别从临床表现、相关药品及剂型、发生时间等方面进行统计分析。结果:87例ADR几乎涉及人体各个系统,发生率最高的是过敏反应;中药注射剂是引起ADR的主要剂型(67.34%);用药当天发生ADR的比例最大(67.82%)。结论:及时报告中药制剂ADR,加强对其监测与研究,有助于减少和避免中药制剂ADR的发生,保障患者用药安全。

ADRs Induced by Chinese Materia Medica Preparation: Analysis of 87 Cases

OBJECTIVE: To discuss the characteristics and influencing factors of ADRs induced by Chinese materia medica preparations and to promote rational drug use in the clinic. METHODS: Using regression analysis method, 87 ADR cases induced by Chinese materia medica preparations reported in our hospital in 2006 were analyzed statically in respect to clinical manifestations, related drugs and dosage forms, and the time of onset etc. RESULTS: The 87 ADR cases involved almost all the body systems, which manifested predominantly by allergic reactions. 67. 34% of the adverse reactions were induced by Chinese materia medica preparations, and 67. 82% occurred within 24h after medication. CONCLUSION: Timely reporting of Chinese materia medica preparations-induced ADRs, strengthened monitoring and research of which may help to reduce and avoid the ADRs incidences induced by Chinese materia medica preparations and ensure patients' medication safety.