支气管肺泡灌洗联合小剂量罗红霉素治疗支气管扩张症的临床观察

目的:观察支气管肺泡灌洗联合小剂量罗红霉素口服治疗支气管扩张症的临床疗效。方法:30例支气管扩张症患者随机分为治疗组和对照组各15例,治疗组在常规治疗的基础上行支气管镜下局部病灶所属支气管的肺泡灌洗,同时加用罗红霉素150mg,qd,po;对照组仅用常规治疗,包括:吸氧、止咳化痰药物和抗感染治疗,但不使用其它大环内酯类药物和激素。治疗6个月后观察2组患者的临床疗效、咳痰量、肺功能变化和病情急性加重次数。结果:治疗组6个月内急性发作次数显著低于对照组;咯痰量明显减少(P<0.05),第1秒用力呼气容积(FEV1)、FEV1/用力肺活量(FVC)均高于对照组(P<0.05)。结论:支气管肺泡灌洗联合小剂量罗红霉素口服,可以改善支气管扩张症患者的临床症状、肺功能,降低急性发作频率。

Clinical Observation of Bronchoalveolar Lavage Combined with Low Dose of Roxithromycin in the Treatment of Bronchiectasis

OBJECTIVE：To investigate the clinical efficacy of bronchoalveolar lavage combined with low dose of roxithromycin in the treatment of bronchiectasis.METHODS：30 patients with bronchiectasis were randomly divided into therapy group and control group.Therapy group（n=15） were given bronchoalveolar lavage of local bronchi under bronchoscope and oral dose of roxithromycin 150 mg once day besides conventional therapy.Control group（n=15） received traditional therapy, including oxygen inhalation, drugs for relieving cough and reducing sputum and antimicrobial agents.Macrolides and corticoids weren＇t adopted.After 6 mnoths of treatment, clinical efficacy, amount of expectoration drainage, pulmonary function and frequency of exacerbations in 2 groups were observed.RESULTS：The frequency of exacerbations in therapy group was lower than in control group; the amount of expectoration drainage reduced significantly （P0.05）.The FEV1 and FEV1/FVC in therapy group were obviously higher than in control group （P0.05）.CONCLUSION：Bronchoalveolar lavage combined with low dose of roxithromycin could improve clinical symptoms, pulmonary function, and decrease the frequency of exacerbations in patients with bronchiectasis.