| 螺旋藻多糖对小鼠腹腔巨噬细胞游离Ca~(2+)浓度的影响 |
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| 引用本文： | 孙伟,李静,韩志武.螺旋藻多糖对小鼠腹腔巨噬细胞游离Ca~(2+)浓度的影响[J].中国药房,2000,11(5):205-206. |
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| 作者姓名： | 孙伟 李静 韩志武 |
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| 作者单位： | 青岛大学医学院附属医院,青岛市 |
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| 摘 要： | 目的 :研究探讨螺旋藻多糖 (SPP)的免疫调节机制。方法 :采用荧光分光光度法 ,测定SPP对小鼠腹腔巨噬细胞 (MΦ)游离Ca2 +浓度 (Ca2 +]i)的影响。结果 :SPP能剂量依赖性地引起小鼠腹腔MΦCa2 +]i 明显升高 ,Ca2 +]i 的升高是由胞外钙内流和胞内钙释放共同作用的结果。结论 :SPP所产生的免疫调节作用与其能够使巨噬细胞Ca2 +]i 升高有关。
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| 关 键 词： | 螺旋藻多糖 游离Ca~(2+)浓度 巨噬细胞 荧光分光光度法 |
| 文章编号： | 1001-0408(2000)05-0205-02 |
| 修稿时间： | 2000年2月1日 |
Effect of Spirulina Platensis Polysaccharide on Concentration of Intracellular Free Calcium in Murine Peritoneal Macrophages |
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| SUN Wei,LI Jing,HAN Zhiwu.Effect of Spirulina Platensis Polysaccharide on Concentration of Intracellular Free Calcium in Murine Peritoneal Macrophages[J].China Pharmacy,2000,11(5):205-206. |
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| Authors: | SUN Wei LI Jing HAN Zhiwu |
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| Abstract: | OBJECTIVE:To study the immunoregulatory action of Spirulina platensis polysaccharide(SPP).METHODS:A fluorospectrophotometric method of fluorescent indicator dye Fluo-3/AM was used to investigate the effect of SPP on intracellular free calcuim in murine peritoneal macrophages.RESULTS:SPP increased i in a concentration-dependent manner in murine peritoneal macrophages by inducing both extracellular Ca2 influx and intracellular Ca2 release.The increase in i was referable to its effect on Ca2 channel.CONCLUSION:The results shows that the most important immunoregulatory action of SPP is to increase i in macrophages. |
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| Keywords: | Spirulina platensis polysaccharide intracellular free calcium macrophage fluorospectrophotometry |
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