布托啡诺和芬太尼伍用异丙酚后对自主呼吸的影响 |
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引用本文: | 祝贵州,;丁洁卫,;陈忠华,;易声华,;江华勇,;胡君凤.布托啡诺和芬太尼伍用异丙酚后对自主呼吸的影响[J].中国药房,2009(8):603-605. |
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作者姓名: | 祝贵州 ;丁洁卫 ;陈忠华 ;易声华 ;江华勇 ;胡君凤 |
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作者单位: | [1]浙江绍兴市人民医院麻醉科,绍兴市312000; [2]浙江绍兴市人民医院药剂科,绍兴市312000 |
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摘 要: | 目的:观察布托啡诺和芬太尼伍用异丙酚后对自主呼吸的影响。方法:选择80例门诊择期行肠镜检查的患者,随机分成2组,A组布托啡诺+异丙酚,B组芬太尼+异丙酚。记录不同时段的循环体征、呼吸参数和听觉诱发电位,同时记录不良反应及药物用量。结果:在麻醉深度相同的情况下,2组血压、脉搏差异无统计学意义。2组患者的1~5min通气量均明显低于基础值,而芬太尼使这一趋势更加明显。B组发生的呼吸系统问题明显高于A组。结论:布托啡诺对自主呼吸抑制较轻微,不良反应少,是一种适用于门诊短小手术的麻醉药品。
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关 键 词: | 自主呼吸 布托啡诺 芬太尼 异丙酚 |
Effects of Propofolum in Combination with Butorphanol or with Fentanyi on Spontaneous Breathing |
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Institution: | ZHU Gui-zhou, CHEN Zhong-hua, YI Sheng-hua, JIANG Hua-yong, HU Jun-feng,DING Jie-wei(Dept. of Anesthesiology, Zhejiang Shaoxing People's Hospital, Shaoxing 312000, China;Dept. of Pharmacy, Zhejiang Shaoxing People's Hospital, Shaoxing 312000, China) |
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Abstract: | OBJECTIVE: To investigate the effects of Propofolum in combination with Butorphanol or with Fentanyl on spontaneous breathing. METHODS: 80 outpatients undergoing scheduled enteroscopy were randomized to Group A (butorphanol in combination with Propofolum) or Group B (Fentanyl in combination with Propofolum) . The cardiovascular signs, respiration parameters and the auditory evoled potential (AEP) at different period of time as well as the adverse reaction and doses were recorded. RESULTS: Regarding the cardiovascular indexes, there were no statistically differences in blood pressure and arterial pulse between the two groups under the same depth of anesthesia. The 1-5 minute ventilation in the two groups were all significantly lower as compared with their baseline levels, much as in the Fentanyl - treated group. The incidence of adverse events of respiratory system in Fentanyl - treated group was significantly higher than in Butorphanol - treated group. CONCLUSION: Butorphanol is a preferred narcotic therapy for outpatient minor operation in that it has mild depressive effect on spontaneous breathing and fewer adverse reactions as compared with Fentanyl. |
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Keywords: | Spontaneous breathing Butorphanol Fentanyl Propofolum |
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