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注射用加替沙星与注射用法莫替丁的配伍稳定性考察
引用本文:杨继章,赵增仁,刘瑞琴,杨树民,佟彬良.注射用加替沙星与注射用法莫替丁的配伍稳定性考察[J].中国药房,2007,18(20):1563-1565.
作者姓名:杨继章  赵增仁  刘瑞琴  杨树民  佟彬良
作者单位:1. 河北医科大学第一医院药剂科,石家庄市,050031
2. 河北医科大学药学院,石家庄市,050017
基金项目:河北省医学科学研究重点项目
摘    要:目的:考察注射用加替沙星与注射用法莫替丁在0.9%氯化钠注射液和5%葡萄糖注射液中的配伍稳定性。方法:在(20±1)℃条件下,分别观察及测定8h内配伍液的外观、pH值及紫外光谱的变化,并用紫外分光光度法测定加替沙星和法莫替丁的含量。结果:2药配伍后,8h内的pH值及含量均无明显变化;另在0.9%氯化钠注射液中8h内与5%葡萄糖注射液中6h内,配伍液的外观无明显变化。结论:注射用加替沙星与注射用法莫替丁在0.9%氯化钠注射液和5%葡萄糖注射液中配伍稳定。

关 键 词:注射用加替沙星  注射用法莫替丁  配伍  稳定性  紫外分光光度法
文章编号:1001-0408(2007)20-1563-03
收稿时间:2006-12-31
修稿时间:2006-12-312007-04-19

Compatibility of Gatifloxacin for Injection with Famotidine for Injection
YANG Jizhang,ZHAO Zengren,LIU Ruiqin,YANG Shumin,TONG Binliang.Compatibility of Gatifloxacin for Injection with Famotidine for Injection[J].China Pharmacy,2007,18(20):1563-1565.
Authors:YANG Jizhang  ZHAO Zengren  LIU Ruiqin  YANG Shumin  TONG Binliang
Abstract:OBJECTIVE:To study the compatibility of gatifloxacin for injection with famotidine for injection in 0.9% sodium chloride injection or 5% glucose injection.METHODS:At room temperature ((20±1)℃)for 8 hours,the changes of the mixture in appearance,pH and UV spectra were observed,and the contents of gatifloxacin and famotidine were determined by ultraviolet spectrophotometry.RESULTS:No significant change was found in pH values and contents within 8h after mixing of the two drugs,nor significant changes were found for the mixture in appearance within 8h in 0.9% sodium chloride injection or within 6h in 5% glucose injection.CONCLUSION: The mixture of gatifloxacin for injection and famotidine for injection were stable in 0.9% sodium chloride injection or 5% glucose injection.
Keywords:Gatifloxacin for injection  Famotidine for injection  Compatibility  Stability  UV spectrophotometry
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