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| 康视明合剂质量标准研究 | |
| 引用本文： | 吴樱,杨义芳,罗明琍,邓晓丽.康视明合剂质量标准研究[J].中国药房,2008,19(27):2133-2135. |
| 作者姓名： | 吴樱 杨义芳 罗明琍 邓晓丽 |
| 作者单位： | 1. 上海市中医医院药剂科,上海市,200071 2. 上海医药工业研究院中药研究室,上海市,200040 3. 岛津国际贸易(上海)有限公司上海分析中心,上海市,200020 |
| 摘 要： | 目的:建立康视明合剂的质量标准。方法:采用高效薄层色谱(HPTLC)法对方中黄柏、枳壳、白芍、当归、葛根进行定性鉴别;采用超快速高效液相色谱法测定柚皮苷和甘草酸铵的含量。结果:HPTLC的斑点清晰、分离度较好,阴性无干扰;柚皮苷、甘草酸铵的进样量分别在0.015～0.135μg(r=0.9999)、0.1～0.9μg(r=0.9999)范围内与各自峰面积积分值呈良好的线性关系;平均加样回收率分别为97.78%、101.99%,RSD分别为2.19%(n=6)、1.95%(n=6)。结论:所建标准可用于康视明合剂的质量控制。 |
| 关 键 词： | 康视明合剂 质量标准 高效薄层色谱法 超快速高效液相色谱法 |
Quality Standard of Kangshiming Mixture |
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| WU Ying,YANG Yi-fang,LUO Ming-li,DENG Xiao-li.Quality Standard of Kangshiming Mixture[J].China Pharmacy,2008,19(27):2133-2135. | |
| Authors: | WU Ying YANG Yi-fang LUO Ming-li DENG Xiao-li |
| Institution: | WU Ying,YANG Yi-fang,LUO Ming-li, DENG Xiao-li(1Dept.of Pharmacy, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai 200071, China;2Dept. of Chinese Materia Medica,Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China;3Shimadzu International Trading (Shanghai) Co., Limited, Shanghai Customer Support Center, Shanghai 200020, China) |
| Abstract: | OBJECTIVE：To establish the quality standard of Kangshiming mixture.METHODS： The Phellodendron chinense , Citrus anrantium , Paeonia lacti flora , Angelica sinensis , and Pueraria lobata in Kangshiming mixture were identified by HPTLC and the contents of Naringin and Ammonium glycyrrhizinate were determined by UFLC.RESULTS： The spots in the HPTLC were clear and well - separated yet free of interference of negative sample.The linear ranges of Naringin and Ammonium glycyrrhizinate were 0.015-0.135μg（r = 0.999 9） and 0.1-0.9μg （r = 0.999 9）, respectively, and their recovery rates were 97.78 % （RSD = 2.19 %, n = 6） and 101.99 % （1.95 %, n = 6）, respectively. CONCLUSION ： The established standard is applicable for the quality control of Kangshiming mixture. |
| Keywords: | Kangshiming mixture Quality standard HPTLC UFLC |
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