| 干扰素α联合拉米夫定治疗慢性乙型肝炎疗效观察 |
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| 引用本文： | 刘再伏.干扰素α联合拉米夫定治疗慢性乙型肝炎疗效观察[J].中国药房,2006,17(20):1569-1570. |
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| 作者姓名： | 刘再伏 |
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| 作者单位： | 湖北省宜城市人民医院,宜城市,441400 |
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| 摘 要： | 目的:观察干扰素α联合拉米夫定治疗慢性乙型肝炎的疗效。方法:72例慢性乙型肝炎患者随机分为治疗组与对照组。治疗组35例,同时使用干扰素α及拉米夫定26wk后,再单独使用拉米夫定26wk;对照组37例,单独使用拉米夫定52wk。结果:治疗组与对照组HBeAg转阴率分别为42.86%、27.03%(P>0.05),HBVDNA转阴率分别为94.29%、62.16%(P<0.05)。结论:干扰素α联合拉米夫定治疗慢性乙型肝炎效果略优于单独使用拉米夫定。
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| 关 键 词： | 干扰素α 拉米夫定 联合治疗 慢性乙型肝炎 |
| 文章编号： | 1001-0408(2006)20-1569-02 |
| 收稿时间： | 12 14 2005 12:00AM |
| 修稿时间： | 01 23 2006 12:00AM |
Observation of Curative Effect of Interferon - α in Combination with Lamivudine for Chronic Hepatitis B |
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| LIU Zaifu.Observation of Curative Effect of Interferon - α in Combination with Lamivudine for Chronic Hepatitis B[J].China Pharmacy,2006,17(20):1569-1570. |
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| Authors: | LIU Zaifu |
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| Abstract: | OBJECTIVE:To evaluate the efficacy of interferon-α in combination with lamivudine for chronic hepatitis B.METHODS:A total of 72 patients with hepatitis B were randomized into 2 groups:35(treatment group)were assigned to receive interferon-α plus lamivudine for 26 weeks before receiving lamivudine alone for another 26 weeks,and 37(control group)to receive lamivedine alone for 52 weeks.RESULTS:Proportions of HbeAg seroconversion in treatment group and control group were 42.86% and 27.03%,respectively(P>0.05)and proportions of HBV DNA seroconversion were 94.29% and 62.16%,respectively(P<0.05).CONCLUSION:The curative effect of interferon-α in combination with that of lamivudine is better than lamivudine alone for chronic hepatitis B. |
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| Keywords: | Interferon-α Lamivudine Drug combination Chronic hepatitis B |
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