| 149例喹硫平致不良反应报告分析 |
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| 引用本文： | 沈剑文,马燕,毛叶萌.149例喹硫平致不良反应报告分析[J].中国药房,2011(32):3031-3033. |
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| 作者姓名： | 沈剑文 马燕 毛叶萌 |
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| 作者单位： | 复旦大学附属眼耳鼻喉科医院;上海交通大学医学院附属精神卫生中心; |
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| 摘 要： | 目的:分析喹硫平药品不良反应的特点,为精神科临床用药提供参考。方法:对2004年1月-2010年7月在上海市精神卫生中心就诊并使用喹硫平发生不良反应的患者进行回顾性调查、分析。结果:喹硫平最常见的不良反应为中枢及外周神经系统损害,占20.7%,临床表现为锥体外系反应、头晕、嗜睡等;其次为肝胆系统损害,占18.1%,表现为肝功能异常、丙氨酸氨基转移酶和天冬氨酸氨基转移酶升高。1周内发生反应为36例,占24.2%;28d内发生反应89例,占59.7%。关联性评价中,报告评定为可能的为125例(83.9%)。结论:喹硫平的药品不良反应虽较少,但其不良反应依然需要高度重视。
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| 关 键 词： | 喹硫平 药品不良反应 药品安全 |
Analysis of 149 Adverse Drug Reaction Reports Induced by Quetiapine |
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| SHEN Jian-wen MA Yan,MAO Ye-meng.Analysis of 149 Adverse Drug Reaction Reports Induced by Quetiapine[J].China Pharmacy,2011(32):3031-3033. |
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| Authors: | SHEN Jian-wen MA Yan MAO Ye-meng |
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| Institution: | SHEN Jian-wen(The Affiliated EYE&ENT Hospital of Fudan University,Shanghai 200031,China) MA Yan,MAO Ye-meng(Mental Health Center of Shanghai Jiaotong University School of Medicine,Shanghai 200030,China) |
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| Abstract: | OBJECITVE: To analyze the characteristics of adverse drug reaction reports induced by quetiapine, and to provide references for clinical drug use in psychiatric department. METHODS: Adverse drug reaction reports induced by quetiapine in Shanghai Mental health Center from Jan. 2004 to Jul. 2010 were investigated retrospectively. RESULTS: The most common adverse drug reactions induced by quetiapine were central and peripheral nervous system disorders, accounting for 20.7%, including extrapyramidal disease, di... |
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| Keywords: | Quetiapine Adverse drug reaction Drug safety |
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