| RP-HPLC法测定甲磺酸酚妥拉明滴鼻剂中甲磺酸酚妥拉明的含量 |
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| 引用本文： | 叶勇,晏亦林,张健泓. RP-HPLC法测定甲磺酸酚妥拉明滴鼻剂中甲磺酸酚妥拉明的含量[J]. 中国药房, 2011, 0(28): 2680-2682 |
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| 作者姓名： | 叶勇 晏亦林 张健泓 |
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| 作者单位： | 广西医科大学;广东食品药品职业学院; |
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| 摘 要： | 目的:建立测定甲磺酸酚妥拉明滴鼻剂中甲磺酸酚妥拉明含量的方法。方法:采用反相高效液相色谱法。色谱柱为Hy-p2e7r8s inl mB,D流S速C1为8硅1烷.0键mL合.硅mi胶n-柱1,进,流样动量相为为100μ.2L%,柱甲温酸为-2.255%℃磷。酸结二果氢:钾甲溶磺液酸-酚乙妥腈(拉4明8∶进15样∶3量7,在三0乙.10胺0调4～节0.p6H02至4 4μ.g0)范,检围测内波与长峰面为积积分值线性关系良好(r=0.999 9);平均回收率为99.69%(n=9,RSD=0.73%)。结论:本法准确、可靠、专属性强,可用于甲磺酸酚妥拉明滴鼻剂的质量控制。
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| 关 键 词： | 甲磺酸酚妥拉明 滴鼻剂 高效液相色谱法 |
Content Determination of Phentolamine Mesylate Nasal Drops by RP-HPLC |
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| YE YongYAN Yi-lin,ZHANG Jian-hong. Content Determination of Phentolamine Mesylate Nasal Drops by RP-HPLC[J]. China Pharmacy, 2011, 0(28): 2680-2682 |
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| Authors: | YE YongYAN Yi-lin ZHANG Jian-hong |
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| Affiliation: | YE Yong(Guangxi Medical University,Nanning 530021,China)YAN Yi-lin,ZHANG Jian-hong(Guangdong Food and Drug Vocational College,Guangzhou 510520,China) |
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| Abstract: | OBJECTIVE： To establish the method for the content determination of Phentolamine mesylate nasal drops. METH- ODS： RP-HPLC method was adopted. The determination was performed on Hypersil BDS C18 with mobile phase consisted of 0.2 % formic acid-2.5% potassium dihydrogen phosphate -acetonitrile （48： 15：37, pH adjusted to 4.0 with triethylamine） at flow rate of 1.0 mL.min-l. The detection wavelength was set at 278 nm and injection volume was 10 μL. The column temperature was 25 ~12. RESULTS： The linear range of phentolamine mesylate were 0.100 4~0.602 4 μg （r=0.999 9） with an average recovery, of 99.69% （n=9, RSD=0.73% ）. CONCLUSION： The method is reliable, specific and suitable for the quality control of Phentot- amine mesylate nasal drops. |
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| Keywords: | Phentolamine mesylate Nasal drops HPLC |
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