生化汤药动学及其血清指纹图谱研究

目的:研究生化汤的药动学及不同时间的血清指纹图谱。方法:采用高效液相色谱法测定阿魏酸含量,进行药动学参数研究;并与血清指纹图谱结合探讨生化汤中的活性成分。结果:兔口服生化汤后体内阿魏酸的分布代谢呈二室模型;不同时间的血清指纹图谱与空白血清指纹图谱有显著不同。结论:用血清指纹图谱监测到阿魏酸的含量变化符合生化汤中阿魏酸的药动学规律。此法有助于阐明生化汤的药动学特性、药理活性及作用机制。

Pharmacokinetics and Serum Fingerprints of Decoction for Puerperal Blood Stasis

OBJECTIVE： To study the pharmacokinetics and serum fingerprints of Decoction for Puerperal Blood Stasis at different time. METHODS： The content of Ferulaic acid （FA） was determined by HPLC. The pharmacokinetic study was carried out. The active constituent in the Decoction for Puerperal Blood Stasis was analyzed based on the serum fingerprints of FA. RESULTS： The distribution and metabolism of FA in rabbits after oral administration of Decoction for Puerperal Blood Stasis assummed two compartment model. The fingerprints between serum at different time and blank serum showed significant differences. CONCLUSION： The content change of FA monitored with serum fingerprints was in line with the rule of pharmacokinetics of FA in Decoction for Puerperal Blood Stasis. The fingerprints can be applied to clarify the pharmacokinetic characteristics, the pharmacological action and the action mechanism of Decoction for Puerperal Blood Stasis.