首页 | 本学科首页   官方微博 | 高级检索  
检索        

黄芩苷分散片的制备及质量控制
引用本文:宋群亮,张平,夏源,孙旭群,夏泉.黄芩苷分散片的制备及质量控制[J].中国药房,2007,18(15):1144-1146.
作者姓名:宋群亮  张平  夏源  孙旭群  夏泉
作者单位:1. 安徽医科大学药学院,合肥市,230032
2. 安徽医科大学药学院,合肥市,230032;安徽医科大学第一附属医院药剂科,合肥市,230022
3. 合肥恒星药物研究所,合肥市,230051
4. 安徽医科大学第一附属医院药剂科,合肥市,230022
摘    要:目的:制备黄芩苷分散片并建立其质量控制方法。方法:以崩解时间为指标,采用正交设计试验对黄芩苷分散片的处方进行优化,并采用HPLC法测定其含量和溶出度。结果:优化处方为交联聚维酮40%、羧甲基淀粉钠6%和预胶化淀粉2%;按优化处方制备的黄芩苷分散片在3min内完全崩解,15min溶出度达到90%以上。结论:本制备工艺简单、可行;所制分散片崩解迅速、溶出度高。

关 键 词:黄芩苷  分散片  正交试验  含量测定  溶出度
文章编号:1001-0408(2007)15-1144-03
收稿时间:10 15 2006 12:00AM
修稿时间:12 17 2006 12:00AM

Preparation and Quality Control of Baicalin Dispersible Tablets
SONG Qunliang,ZHANG Ping,XIA Quan,SUN Xuqun,XIA Yuan.Preparation and Quality Control of Baicalin Dispersible Tablets[J].China Pharmacy,2007,18(15):1144-1146.
Authors:SONG Qunliang  ZHANG Ping  XIA Quan  SUN Xuqun  XIA Yuan
Institution:1.College of Pharmacy, Anhui Medical University, Hefei 230032, China;2.Dept, of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;3.Hefei Hengxing Institute of Pharmaceutical Research, Hefei 230051, China
Abstract:OBJECTIVE: To prepare Baicalin dispersible tablets and establish a quality control method for this preparation. METHODS: The formula of Baicalin dispersible tablets was optimized by orthogonal experiment with disintegrating time as index. The content and dissolution rate of the tablets were determined by HPLC. RESULTS: The optimized formula was as follows: the contents of crospovidone, sodium starch glycolate and amylum pregelatinisatum were 40%, 6% and 2%, respectively. The dispersible tablets prepared in accordance with the optimize formula could disintegrate completely within 3 minutes and its dissolution rate could reach beyond 90% in 15 minutes. CONCLUSION: The preparation process is simple and feasible, and the prepared Baicalin dispersible tablets had a rapid disintegration and high dissolution rate.
Keywords:Baicalin  Dispersible tablets  Orthogonal experiment  Content determination  Dissolution rate
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号