| 双硫腙水相分光光度法测定维参锌胶囊中锌的含量 |
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| 引用本文： | 黄小玉,;雷光洪,;杨国章,;尚京川,;方志娥,;袁泰先.双硫腙水相分光光度法测定维参锌胶囊中锌的含量[J].中国药房,2009(13):1021-1022. |
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| 作者姓名： | 黄小玉 ;雷光洪 ;杨国章 ;尚京川 ;方志娥 ;袁泰先 |
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| 作者单位： | [1]重庆医科大学药学院,重庆市400016; [2]青阳药业有限公司,重庆市400025; [3]中山市东升医院,中山市528414; [4]重庆医科大学医学检验系,重庆市400016 |
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| 摘 要： | 目的:建立以双硫腙水相分光光度法测定维参锌胶囊中锌含量的方法。方法:在非离子表面活性剂吐温-80存在下,以醋酸-醋酸钠(pH4.5)为缓冲介质,利用锌离子与双硫腙形成稳定的配合物,在535nm波长处采用分光光度法测定并计算维参锌胶囊中锌的含量。结果:锌检测浓度的线性范围为0.172～1.204μg.mL-1(r=0.999 3);平均回收率为99.20%,RSD=0.94%。结论:本方法操作简便、灵敏、准确,可用于维参锌胶囊中锌的含量测定。
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| 关 键 词： | 双硫腙 水相 分光光度法 维参锌胶囊 含量测定 |
Determination of Zinc in Weishenxin Capsule by Dithizone Spectrophotometry in Water Phase |
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| Institution: | HUANG Xiao-yu, SHANG Jing-chuan, FANG Zhi-e,LEI Guang-hong,YANG Guo-zhang,YUAN Tai-xian (School of Pharmacy, Chongqing Medical University, Chongqing 400016, China;Oingyang Pharmaceutical Co. Ltd., Chongqing 400025, China;Zhongshan Municipal Dongsheng Hospital, Zhongshan 528414, China;Dept. of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, China) |
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| Abstract: | OBJECTIVE： To determine the content of zinc in weishenxin capsule by dithizone - spectrophotometry in water phase. METHODS： A stable coordination compound of zinc ion and dithizone was formed in acetic acid - sodium acetate （pH = 4.5） buffer solution with the presence of nonionic wetting agent tween 80. The content of zinc in weishenxin capsule was determined under a wavelength of 535 nm by spectrophotometry. RESULTS： The linear range of zinc was 0.172 ～1.204μg·mL^-1 （r=0.999 3） with an average recovery rate of 99.20% （RSD = 0.94% ）. CONCLUSION： The method is simple, sensitive, accurate and applicable for the determination of the content of zinc in weishenxin capsule. |
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| Keywords: | Dithizone Water phase Spectrophotometry Weishenxin capsule Content determination |
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