雄黄水飞炮制工艺及其机制研究

目的:对雄黄水飞炮制工艺进行优化并探讨其机制。方法:以氢化物发生原子荧光光谱法测定炮制品中As2O3的含量,以显微镜下动态观察结果、成品收率、As2O3含量等多项指标对雄黄水飞炮制工艺进行系统研究。结果:研究雄黄最佳水飞工艺需要进行加液研磨至糊状的加水量和时间考察、研磨成糊状后搅拌的加水量及其停置时间考察、水飞法合并混悬液静置时间考察以及水飞法干燥温度考察,并使炮制品粒度圆整均匀,粒径达到<5μm。结论:本研究验证并优化了雄黄水飞炮制工艺,使炮制品有毒成分含量显著降低。

Mechanism of Water Grind Processing of Realgar

OBJECTIVE： To optimize the water grind processing of Realgar.METHODS： The content of As2O3 in the processed product was determined by Hydride generation atomic fluorescence speetrometry.A systematic study was performed on realgar＇s water grind processing based on dynamic observation under a microscope, product yield, the content of As2O3 etc. RESULTS： The optimized water grind processing of Realgar was as follows： grinding Realgar into paste while adding water with the amount of water and the grinding time investigated; investigating the amount of water added for the grinding of the paste and its Resting time; investigating the standing time of suspension water in the water grind processing, and investigating the drying temperature in the water grind processing. Meanwhile, the grain size of the processed product was processed into round and uniform in shape with their particle size at less than 5μm. CONCLUSION： The study has validated and optimized the water grind processing of Realgar and contributed to the reduction of the contents of poisonous components in the processed product.