| 正交试验优化鼻渊灵颗粒中挥发油的包合工艺 |
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| 引用本文： | 李春花,李清,宋晓宇,张志坤,付青莲.正交试验优化鼻渊灵颗粒中挥发油的包合工艺[J].中国药房,2006,17(3):180-181. |
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| 作者姓名： | 李春花 李清 宋晓宇 张志坤 付青莲 |
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| 作者单位： | 1. 河北医科大学中医学院中药药剂教研室,石家庄市,050091
2. 河北医科大学中药系,石家庄市,050091 |
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| 摘 要： | 目的优选β-环糊精包合鼻渊灵颗粒剂中薄荷、辛夷、藿香3味药材混合挥发油的最佳工艺条件。方法采用正交试验法,以挥发油包合率、包合物收得率、包合物含油率为指标,评价包合工艺条件。结果挥发油与β-环糊精之比1∶8(ml∶g)、超声时间10min、超声水温20℃为最佳工艺条件。结论优选工艺方法简单,效率较高,适合工业化生产。
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| 关 键 词： | 鼻渊灵颗粒剂 挥发油 β-环糊精 包合 正交试验 |
| 文章编号： | 1001-0408(2006)03-0180-02 |
| 收稿时间： | 08 5 2005 12:00AM |
| 修稿时间： | 11 15 2005 12:00AM |
Optimizing the Inclusion Process of Volatile Oil in Biyuanling Granules through Orthogonal Experiment |
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| LI Chunhua,Li Qing,SONG Xiaoyu,ZHANG Zhikun,FU Qinglian.Optimizing the Inclusion Process of Volatile Oil in Biyuanling Granules through Orthogonal Experiment[J].China Pharmacy,2006,17(3):180-181. |
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| Authors: | LI Chunhua Li Qing SONG Xiaoyu ZHANG Zhikun FU Qinglian |
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| Institution: | 1.Dept .of Chinese Drugs Medicament,TCM College,Hebei Medical University, Shijiazhuang 050091, China;2.Dept. of TCM, Hebei Medical University, Shij iazhuang 050091, China |
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| Abstract: | OBJECTIVE:To optimizeβ-cyclodextrin inclusion process in the inclusion of volatile oil compounds of peppermint,biond magnolia flower and agastache rugosa in biyuanling granules.METHODS:Orthogonal experiment was performed,the inclusion process was evaluated with inclusion rate of volatile oil,recovery rate of inclusion compound,extract ratio of inclusion compound as indexes.RESULTS:The optimized inclusion condition was as follows,the ratio of volatile oil toβ-cyclodextrin was1∶8(ml/g)with10min ultrasound time and20℃ultrasound water temperature.CONCLUSIONS:The optimized method was simple and efficient,and suitable for industrialized production. |
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| Keywords: | Biyuanling granules Volatile oil β-cyclodextrin Inclusion Orthogonal experiment |
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