| 盐酸川芎嗪脂质体的研制及其质量评价 |
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| 引用本文： | 黄义昆,张志荣,杜娟,梁建成,覃文安,韦敏.盐酸川芎嗪脂质体的研制及其质量评价[J].中国药房,2004,15(6):343-345. |
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| 作者姓名： | 黄义昆 张志荣 杜娟 梁建成 覃文安 韦敏 |
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| 作者单位： | 1. 广西医科大学附属第五医院,柳州市,545001
2. 四川大学华西药学院,成都市,610041 |
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| 摘 要： | 目的 :研究并评价盐酸川芎嗪脂质体的工艺及其质量。方法 :试验多种方法制备脂质体 ,考察主动载药与被动载药方法制备的脂质体的包封率。结果 :以主动载药制备方法中硫酸铵梯度法所得的脂质体包封率最高 ,达48.63 %;脂质体平均粒径为6.5μm ,经4℃～10℃贮放1mo稳定。结论 :用硫酸铵梯度法制备盐酸川芎嗪脂质体方法可行 ,可为开发盐酸川芎嗪新剂型提供实验依据。
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| 关 键 词： | 盐酸川芎嗪 脂质体 研制 质量评价 |
| 文章编号： | 1001-0408(2004)06-0343-03 |
| 修稿时间： | 2003年11月10 |
Preparation of Ligustrazine Hydrochloride Liposome and Evaluation of the Quality |
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| HUANG Yikun,DU Juan,LIANG Jiancheng,QIN Wenan,WEI Min.Preparation of Ligustrazine Hydrochloride Liposome and Evaluation of the Quality[J].China Pharmacy,2004,15(6):343-345. |
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| Authors: | HUANG Yikun DU Juan LIANG Jiancheng QIN Wenan WEI Min |
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| Abstract: | OBJECTIVE:To study the preparation of the ligustrazine hydrochloride liposome and evaluate its quality.METHODS:The liposome was prepared by various methods on a trial basis.The entrapped efficiency(EE)of the liposome derived from passive loading and active loading was compared.RESULTS:The ammonim sulfate gradient technology had the highest EE of 48.63%and its mean size was 6.5μm and the pH was 5.93.It was stable in refrigeratory(4℃～10℃)storage for 30 days.CONCLUSION:The ammonim sulfate gradient technology of preparation of the ligustrazine hydrochloride liposome is feasible. |
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| Keywords: | ligustrazine hydrochloride liposome trial-production quality evaluation |
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