| 芦氟沙星滴眼液的研制及临床应用 |
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| 引用本文： | 李新田,王向阳,张连强.芦氟沙星滴眼液的研制及临床应用[J].中国药房,2002,13(2):83-84. |
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| 作者姓名： | 李新田 王向阳 张连强 |
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| 作者单位： | 解放军第三医院,宝鸡市721004 |
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| 摘 要： | 目的 :研制芦氟沙星滴眼液。方法 :采用HPLC法测定滴眼液芦氟沙星含量 ;对150例门诊眼部重症感染患者应用该滴眼液后进行疗效观察。结果 :芦氟沙星平均回收率为100 12 % ,RSD为1 18 % (n=5) ;治疗后痊愈130例 ,有效16例 ,无效4例 ,总有效率为97 33 %。结论 :HPLC法测定含量简便、快速、准确 ,不需要特殊试剂 ;该滴眼液疗效确切
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| 关 键 词： | 芦氟沙星 滴眼液 质量控制 临床应用 |
| 文章编号： | 1001-0408(2002)02-0083-02 |
| 修稿时间： | 2001年5月22日 |
Preparation and Clinical Alinical Application of Rufloxacin Drops |
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| LI Xintian,WANG Xiangyang,ZHANG Lianqiang.Preparation and Clinical Alinical Application of Rufloxacin Drops[J].China Pharmacy,2002,13(2):83-84. |
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| Authors: | LI Xintian WANG Xiangyang ZHANG Lianqiang |
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| Abstract: | OBJECTIVE:To prepare rufloxacin eye drops METHODS:The content of rufloxacin was determined with HPLC method The therapeutic effect of the eye drops was observed in 150 out-patients with severe ocular infections RESULTS:Determined by HPLC method,the average recovery of rufloxacin was 100 12%(RSD=1 18%) After treatment,130 patients recovered,16 improved and had no efficiency with a total effective rate of 97 33% CONCLUSION:The eye drops have definite therapeutic effect The HPLC method is simple,rapid and accurate in determination of the content and no special reagent is needed |
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| Keywords: | rufloxacin eye drops quality control clinical use |
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