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3种中药提取物对幽门螺杆菌的体外联合抗菌效应研究
引用本文:徐帆,李平,楚更五,潘培英,李廷艳.3种中药提取物对幽门螺杆菌的体外联合抗菌效应研究[J].中国药房,2007,18(33):2573-2574.
作者姓名:徐帆  李平  楚更五  潘培英  李廷艳
作者单位:1. 成都军区昆明总医院,昆明市,650032
2. 云南中医学院,昆明市,650200
3. 大理学院,大理市,671000
摘    要:目的:研究黄连、蜂胶、吴茱萸对幽门螺杆菌(Hp)的体外联合抗菌效应。方法:采用棋盘法设计,以琼脂平板法测定两两组合的不同浓度中药提取物对Hp的最低抑菌浓度,计算部分抑菌浓度(FIC)指数并判定联合效应。结果:黄连与蜂胶联合应用后,其FIC指数为0.16(<0.5);黄连与吴茱萸联合应用后,其FIC指数为0.63(>0.5);吴茱萸与蜂胶联合应用后,其FIC指数为0.05(<0.5)。结论:黄连与蜂胶联合应用及吴茱萸与蜂胶联合应用,对Hp表现为协同作用,且吴茱萸与蜂胶联合应用协同作用较强;黄连与吴茱萸联合应用,对Hp表现为相加作用;3种中药提取物之间均无拮抗作用。

关 键 词:黄连  蜂胶  吴茱萸  幽门螺杆菌  联合药敏实验
文章编号:1001-0408(2007)33-2573-02
收稿时间:2007-03-05
修稿时间:2007-07-13

Combined Antibacterial Activity of Three Extractives of Traditional Chinese Drug Against Helicobacter Pylori
XU Fan,LI Ping,CHU Gengwu,PAN Peiying,LI Tingyan.Combined Antibacterial Activity of Three Extractives of Traditional Chinese Drug Against Helicobacter Pylori[J].China Pharmacy,2007,18(33):2573-2574.
Authors:XU Fan  LI Ping  CHU Gengwu  PAN Peiying  LI Tingyan
Institution:Kunming General Hospital of Chengdu Military Region,Kunming 650032,China;Yunnan College of TCM, Kunming 650200, China;Dali College, Dali 671000,China
Abstract:OBJECTIVE:To study the combined antibacterial activity of Rhizoma Coptidis,Bee Propolispro and Fructuts Evodiae against Helicobacter pylori(Hp).METHODS:The protocol was designed by checkboard method.The MICs of Rhizoma Coptidis,Bee Propolispro and Fructuts Evodiae alone or in two-and-two combination against Hp were determined by agar plate method,and the FIC indexes was calculated for the evaluation of the combined effects.RESULTS:When Rhizoma Coptidis combined with Bee Propolispro,the FIC index was 0.16(<0.5)but was 0.63(>0.5)when combined with Fructuts Evodiae;The FIC index was 0.05(<0.5)when Fructuts Evodiae combined with Bee Propolispro.CONCLUSION:Both Rhizoma coptidis in combination with Bee Propolispro or Fructuts Evodiae in combination with Bee Propolispro had synergistic action on Hp,with the latter showing more potent synergistic action.Rhizoma Coptidis combined with Fructuts Evodia had additivity against Hp.No antagonistic actions were noted in Rhizoma Coptidis,Bee Propolispro and Fructuts Evodiae.
Keywords:Rhizoma Coptidis  Bee Propolispro  Fructuts Evodiae  Helicobacter pylori(Hp)  Combined drug susceptibility test
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