| 正交试验优化复方奥硝唑阴道生物黏附膜处方 |
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| 引用本文： | 王利,王法琴,王立宏,刘铭佩,焦海胜.正交试验优化复方奥硝唑阴道生物黏附膜处方[J].中国药房,2012(1):59-61. |
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| 作者姓名： | 王利 王法琴 王立宏 刘铭佩 焦海胜 |
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| 作者单位： | 兰州大学第二医院药剂科;甘肃武威市医院 |
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| 摘 要： | 目的:优化复方奥硝唑阴道生物黏附膜的处方。方法:以辅料酸性壳聚糖浓度、明胶浓度、聚乙烯醇(PVA)浓度及主药浓度为考察因素,以生物黏附力为考察指标,采用正交试验设计优化处方,并测定优化处方的生物黏附力和体外释放度。结果:优化的处方组成是酸性壳聚糖浓度为2.0%,明胶浓度为1.0%,PVA浓度为1.0%,主药浓度为2.0%。优化处方所制3批膜剂的平均生物黏附力为2.1N·cm-2,12h时平均体外累积释放率大于89%。结论:按照优化处方制备的复方奥硝唑阴道生物黏附膜具有较好的生物黏附力和缓释性。
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| 关 键 词： | 奥硝唑 壳聚糖 阴道生物黏附膜 正交试验 处方优化 |
Optimization of the Formulation of Compound Ornidazole Chitosan Vaginal Bioadhesive Film by Orthogonal Experiment |
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| WANG Li,WANG Fa-qin,LIU Ming-pei,JIAO Hai-sheng.Optimization of the Formulation of Compound Ornidazole Chitosan Vaginal Bioadhesive Film by Orthogonal Experiment[J].China Pharmacy,2012(1):59-61. |
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| Authors: | WANG Li WANG Fa-qin LIU Ming-pei JIAO Hai-sheng |
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| Institution: | (Dept.of Pharmacy,Lanzhou University Second Hospital,Lanzhou 730030,China) WANG Li-hong(Wuwei Hospital of Gansu Province,Gansu Wuwei 733000,China) |
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| Abstract: | OBJECTIVE:To optimize the formulation of Compound ornidazole chitosan vaginal bioadhesive film.METHODS:The formulation was optimized by orthogonal design with the chitosan concentration,gelatin concentration,PVA concentration and drug concentration as factors using vertical force as index.The bioadhesiveforce and in vitro drug release rate of the films were measured as well.RESULTS:The optimum formulation was as follows:chitosan 2.0%,gelatin 1.0%,PVA 1.0% and drug 2.0%.The average bioadhesiveness of 3 batches of optimized preparations was 2.1 N·cm-2,and the in vitro drug release rate of the films in 12 h was more than 89%.CONCLUSION:The optimal Compound ornidazole chitosan vaginal bioadhesive film shows proper bioadhesion force and slow-release character. |
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| Keywords: | Ornidazole Chitosan Vaginal bioadhesive film Orthogonal experiment Formulation optimization |
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