| 常用抗癌药物对肺癌的体外敏感性研究 |
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| 引用本文： | 宋毅,潘晓鸥,袁淑兰,廖芸.常用抗癌药物对肺癌的体外敏感性研究[J].中国药房,2003,14(4):243-244. |
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| 作者姓名： | 宋毅 潘晓鸥 袁淑兰 廖芸 |
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| 作者单位： | 四川大学华西医院,成都市,610041 |
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| 摘 要： | 目的 :研究常用抗癌药物对肺癌的体外敏感性。方法 :采用四氮甲唑蓝 (MTT)法检测45例人肺癌新鲜标本对15种临床常用化疗药物的敏感性。结果 :肺癌对卡铂、威猛、吡柔比星、顺铂、博来霉素、甲氨蝶呤、羟基喜树碱较敏感 ;不同个体对同一药物的敏感性不同。结论 :化疗药物的敏感性检测对临床选择化疗药物具有重要的参考价值 ,MTT法为临床肿瘤化疗的药物敏感性检测提供了简便、快速的实验方法。
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| 关 键 词： | 肺癌 药物敏感性 四氮甲唑蓝法 |
| 文章编号： | 1001-0408(2003)04-0243-02 |
| 修稿时间： | 2002年5月14日 |
Study on the in Vitro Sensitivity of Lung Cancer Tissue to Commonly-used Antineoplastics |
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| SONG Yi,PAN Xiaoou,YUAN Shulan,LIAO Yun.Study on the in Vitro Sensitivity of Lung Cancer Tissue to Commonly-used Antineoplastics[J].China Pharmacy,2003,14(4):243-244. |
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| Authors: | SONG Yi PAN Xiaoou YUAN Shulan LIAO Yun |
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| Abstract: | OBJECTIVE:To study the in vitro sensitivity of lung cancer tissue to commonly-used antineoplasˉtics.METHODS:The sensitivity of45fresh samples of human lung cancer to15commonly-used antineoplastics was deterˉmined by MTT method.RESULTS:Lung cancer was more sensitive to CBP,VM26,THP,DDP,BLM,MTX and HCPT.However,there was individual difference in sensitivity to the same drug.CONCLUSION:The sensitivity assay of chemotherapeutic agents could provide important information for selection of the agents and MTT assay is a rapid and simple method for detecting the sensitivity of antineoplastics. |
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| Keywords: | lung cancer sensitivity of drug MTT assay |
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