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| 毛木耳多糖对小鼠腹腔巨噬细胞蛋白激酶A活性的影响 | |
| 引用本文： | 王道福,邵林萍,菊保文,丁望.毛木耳多糖对小鼠腹腔巨噬细胞蛋白激酶A活性的影响[J].中国药房,2001,12(5):263-264. |
| 作者姓名： | 王道福 邵林萍 菊保文 丁望 |
| 作者单位： | 1. 解放军第 89医院, 2. 山东省潍坊市人民医院, 3. 山东省潍坊市药品检验所, |
| 摘 要： | 目的 :观察毛木耳多糖 (APSP)体外对小鼠腹腔巨噬细胞 (MΦ)蛋白激酶A (PKA)活性的影响。方法 :采用反相离子对高效液相色谱法测定MΦ中PKA活力。结果 :毛木耳多糖 (80mg/L)能引起小鼠腹腔MΦ中PKA活性明显升高 ,8min达峰值 ,20min恢复到基础水平 ;8min毛木耳多糖与PKA活性的量效关系具有一定的浓度依赖性。结论 :毛木耳多糖的免疫增强作用与其增强MΦ中PKA活性有关。 |
| 关 键 词： | 毛木耳多糖 巨噬细胞 蛋白激酶A |
| 文章编号： | 1001－ 0408(2001)05－ 0263－ 02 |
| 修稿时间： | 2000年11月6日 |
Effect of Auricularia Polytricha Sacc Polysaccharide on PKA Activity in Murine Peritoneal Macrophages |
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| WANG Daofu,SHAO Lingping,JU Baowen,DING Wang.Effect of Auricularia Polytricha Sacc Polysaccharide on PKA Activity in Murine Peritoneal Macrophages[J].China Pharmacy,2001,12(5):263-264. | |
| Authors: | WANG Daofu SHAO Lingping JU Baowen DING Wang |
| Abstract: | AIM:To investigate the effect of Auricularia Polytricha Sacc Polysaccharide(APSP)on protein kinase A(PKA)activity in murine peritoneal macrophages METHODS:New ion-pair RP-HPLC method was used to determinate the activity of PKA in murine peritoneal macrophages RESULTS:APSP(80mg/L)induced activation of PKA in murine peritoneal macrop_hages;the peak appeared at 8 minutes and the activity of PKA returned to the basic level at 20 minutes CONCLUSION:The immunopoteniating effect of APSP may be associated with its activating effect on PKA in murine peritoneal macrophages |
| Keywords: | Auricularia Polytricha Sacc Polysaccharide macrophage protein kinase A |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |