慢性阻塞性肺疾病住院患者抗菌药物治疗的对比分析Δ

目的:对比分析慢性阻塞性肺疾病(COPD)住院患者抗菌药物治疗的情况,探讨临床药师在COPD住院患者抗菌药物治疗中的积极作用。方法:将2012年在我院呼吸内科住院的COPD患者,按入院顺序进行随机分组,有临床药师参与用药的患者入选药师组(n=150);未经临床药师参与用药的患者入选经验组(n=150)。对两组患者住院期间抗菌药物的应用情况、患者平均住院时间、住院费用、药品费用、抗菌药物费用及比例等情况进行统计、分析。结果:药师组单一用药比例(66.0%)高于经验组(29.3%)(P<0.05),而二联、三联及以上用药比例(分别为21.3%、12.7%)均低于经验组(分别为48.0%、22.7%)(P<0.05)。药师组患者平均住院时间、住院费用、药品费用、抗菌药物费用及比例均低于经验组(P<0.05)。结论:临床药师深入临床,参与临床合理用药,可使药物应用更合理,提高患者的用药依从性,有效降低患者的治疗费用,减轻患者的经济负担,对提高医疗质量具有重要的意义。

Comparative Analysis of Antibacterial Drugs Therapy for COPD Inpatients

OBJECTIVE： To comparatively analyze antibacterial drugs therapy for COPD inpatients, and to investigate the role of clinical pharmacists. METHODS： COPD inpatients in respiratory department of our hospital in 2012 were randomly divided into 2 groups according to admission order： drug use of patients in which clinical pharmacists participated were included in pharmacists group （n=150） ; drug use of patients without clinical pharmacist＇s participation were included in experiential medication group （n= 150）. The utilization of antibacterial drugs during hospitalization was analyzed statistically in respects of average hospitaliza- tion time, hospitalization cost, drug cost, cost and proportion of antibacterial drugs, etc. RESULTS： The utilization rate of single drug （66.0%） in pharmacists group was significantly higher than that （29.3%） in experiential medication group （P〈0.05）, while the utilization rate of two-drug, three-drug and other combination （21.3%, 12.7% ） in pharmacists group were lower than those （48.0%, 22.7% ） in experiential medication group （P〈0.05）. Average hospitalization time, hospitalization cost, drug cost, cost and ratio of antibacterial drugs in pharmacists group were also lower than in experiential medication group （P〈0.05）. CONCLU- SIONS： Clinical pharmacists delve into the clinical practice and participate in rational use of drugs so as to promote rational use of drugs and compliance of patients, reduce treatment cost and relieve economical burden of patients, which is of significance to the improvement of medical quality.