| 阿西美辛分散片的制备及其溶出度评价 |
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| 引用本文： | 李忠思,王玉平,刘振华.阿西美辛分散片的制备及其溶出度评价[J].中国药房,2011(1):39-41. |
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| 作者姓名： | 李忠思 王玉平 刘振华 |
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| 作者单位： | 承德医学院中药研究所河北省中药研究与开发重点实验室;承德医学院附属医院药剂科; |
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| 摘 要： | 目的:制备阿西美辛分散片,并对其进行体外溶出度评价。方法:以阿西美辛为主药,微晶纤维素(MCC)为填充剂,采用湿法制粒法制备片剂;取MCC、羧甲基淀粉钠(CMS-Na)的处方用量及羟丙基甲基纤维素(HPMC)的浓度为因素,崩解时限为指标筛选处方;采用《中国药典》溶出度法第二法,以磷酸盐缓冲液为介质进行体外溶出度考察。结果:最佳处方为MCC 40%、CMS-Na 5%、HPMC 1%;所制片剂呈淡黄色、片面光洁,崩解时限20s,含量、分散均匀性均符合2010年版《中国药典》相关要求;30min内溶出度大于90%。结论:该制剂制备方法简单,分散片溶出速度快且完全。
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| 关 键 词： | 阿西美辛 分散片 制备 正交试验 溶出度 |
Study on the Preparation of Acemetacin Dispersible Tablets and Its Dissolution Rate |
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| LI Zhong-si WANG Yu-ping,LIU Zhen-hua.Study on the Preparation of Acemetacin Dispersible Tablets and Its Dissolution Rate[J].China Pharmacy,2011(1):39-41. |
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| Authors: | LI Zhong-si WANG Yu-ping LIU Zhen-hua |
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| Institution: | LI Zhong-si(Institute of Chinese Materia Medica,Chengde Medical College,Hebei Province Key Laboratory of Research and Development for Chinese Materia Medica,Chengde 067000,China) WANG Yu-ping,LIU Zhen-hua(Dept.of Pharmacy,The Affiliated Hospital of Chengde Medical College,China) |
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| Abstract: | OBJECTIVE:To prepare Acemetacin dispersible tablets and to evaluate the dissolution rate of it in vitro.METHODS:Acemetacin dispersible tablets were prepared with wet granulation using acemetacin as main component and microcrystalline cellulose(MCC)as filler.An orthogonal design was performed to optimize the preparation technology of Acemetacin dispersible tablets with disintegrating time as index and the amount of MCC and CMS-Na,the concentration of HPMC solution as factors.The second determination method o... |
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| Keywords: | Acemetacin Dispersible tablets Preparation Orthogonal test Dissolution rate |
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