| 盐酸左氧氟沙星凝胶的制备及质量控制 |
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| 引用本文： | 张芳向,林朝霞. 盐酸左氧氟沙星凝胶的制备及质量控制[J]. 中国药房, 2006, 17(14): 1068-1069 |
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| 作者姓名： | 张芳向 林朝霞 |
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| 作者单位： | 1. 深圳市龙岗区妇幼保健院,深圳市,518172
2. 深圳市龙岗区中心医院,深圳市,518116 |
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| 摘 要： | 目的制备盐酸左氧氟沙星凝胶并建立其质量控制方法。方法以盐酸左氧氟沙星、丙二醇、甘油、卡波姆-940制备盐酸左氧氟沙星凝胶;采用紫外分光光度法测定其中主药盐酸左氧氟沙星的含量。结果所得凝胶为淡黄色透明胶体;盐酸左氧氟沙星检测浓度在2~10μg/ml范围内与吸收度线性关系良好(r=0.9997),平均回收率为100.15%(RSD=0.31%)。结论本制备工艺简单、稳定,质量控制方法可靠。
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| 关 键 词： | 盐酸左氧氟沙星 凝胶 制备 质量控制 |
| 文章编号： | 1001-0408(2006)14-1068-02 |
| 收稿时间： | 2006-06-01 |
| 修稿时间： | 2006-07-02 |
Preparation and Quality Control of Levofloxacin Hydrochloride Gel |
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| ZHANG Fangxiang,LIN Zhaoxia. Preparation and Quality Control of Levofloxacin Hydrochloride Gel[J]. China Pharmacy, 2006, 17(14): 1068-1069 |
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| Authors: | ZHANG Fangxiang LIN Zhaoxia |
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| Affiliation: | Shenzhen Longgang District Maternal and Child Health Hospital, Shenzhen 518172, China;Shenzhen Longgang Central Hospital, Shenzhen 518116, China |
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| Abstract: | OBJECTIVE: To prepare levofloxacin hydrochloride gel and to establish its quality control method. METHODS: Levofloxacin hydrochloride gel was prepared with levofloxacin hydrochloride, propylene glycol, glycerol and carbomer-940. The content of the principal agent levofloxacin hydrochloride was determined by UV spectrophotometry. RESULTS: The prepared gel appeared amber. The detection concentration of levofloxacin hydrochloride at range of 2～10 μg/ml (r=0.9 997)showed a good linear correlation with absorbability, and the average recovery rate was 100.15% with RSD at 0.31%. CONCLUSION: This preparation is simple in preparation technique, stable in quality and reliable in quality control. |
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| Keywords: | Levofloxacin hydrochloride Gel Preparation Quality control |
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