| HPLC法测定增效联磺制剂中三组分的含量 |
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| 引用本文： | 徐志洲,张桂芳.HPLC法测定增效联磺制剂中三组分的含量[J].中国药品标准,2000,1(3):38-40. |
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| 作者姓名： | 徐志洲 张桂芳 |
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| 作者单位： | [1]山东省药品检验所，济南250012 [2]山东省立医院，济南250021 |
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| 摘 要： | 目的：建立反相高效液相色谱法测定增效联磺制剂中磺胺甲噁唑、磺胺嘧啶与甲氧苄啶三组分的含量。方法：采用Spherisob ODS色谱柱，0．05mol／L磷酸二氢钠-甲醇(75：25)为流动，230nm为检测波长。结果：方法平均回收率：磺胺甲噁唑100．1％，RSD=0．20％(n=6)；磺胺嘧啶100．9％，RSD=0．42％(n=6)；甲氧苄啶99．6％，RSD0．69％(n=6)。结论：方法简便、快捷、准确，是增效联磺制剂质量控制的理想方法。
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| 关 键 词： | 制剂 RSD 磺胺甲噁唑 HPLC法 含量 甲氧苄啶 磺胺嘧啶 三组分 甲醇 增效 |
DETERMINATION OF THREE COMPONENT IN ZENGXIAO LIANHUANG PREPARATIONS BY HPLC |
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| Authors: | Xu Zhizhou and Zhang Guifang |
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| Institution: | Shandong Province Institute for Drug control, Jinan 250012;Shandong Provincial Hospital, Jinan 250021 |
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| Abstract: | Objective: The method of the determination of SMZ, SD and TMP in Zengxiao Lianhuang preparations was established. Method: The method used Spherisorb ODS column, 0.05mol/L sodium dihydrogen phosphate solution-methanol(75.25)as mobile phase and 230nm as detection wavelength. Resuit. The average recoveries of SMZ, SD and TMP were 100.1%, RSD=0.20%(n=6); 100.9%, RSD=0.42%(n=6);99.6%, RSD 0.69%(n=6) respectively. Conclusion. The method is simple, rapid, accurate and suitable for quality control of Zengxiao Lianhuang preparations. |
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| Keywords: | HPLC SMZ SD TMP |
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