首页 | 本学科首页   官方微博 | 高级检索  
检索        

肾石通丸质量标准的研究
引用本文:李虹,郭宏伟,沈书博.肾石通丸质量标准的研究[J].中国药品标准,2012,13(4):268-271.
作者姓名:李虹  郭宏伟  沈书博
作者单位:辽宁省食品药品检验所,沈阳,110023
摘    要:目的:研究肾石通丸的质量标准。方法:薄层鉴别木香、鸡内金、金钱草;RP-HPLC法测定丹参中丹酚酸B的含量。含量测定采用Waters C18色谱柱(4.6 mm×200 mm,5μm),流动相为甲醇-乙腈-甲酸-水(30∶10∶1∶59),流量1 mL.min-1,检测波长286 nm。结果:薄层鉴别阴性对照均无干扰;含量测定丹酚酸B在0.054 67~2.186 69μg范围内有良好的线性关系(r=0.999 9),平均加样回收率为99.0%(n=6)。结论:所建方法简单、可靠,可用于肾石通丸的质量控制。

关 键 词:去氢木香内酯  鸡内金  山柰素  槲皮素  金钱草  丹酚酸B  肾石通丸  高效液相色谱法

Study on Quality Standard for Shenshitong Pills
Authors:Li Hong  Guo Hongwei and Shen Shubo
Institution:(Liaoning Institute for Food and Drug Control , Shenyang 110023 )
Abstract:Objective: To establish a method for the quality standard of Shenshitong Pills. Methods: The TLC methods were established for Aucklandiae Radix ,Galli Gigerii Endothelium Corneum, Lysimachiae Herba and an RP-HPLC methed was established for the deter mination of salvianolic acid B in Shenshitong Pills. Waters Cis (4.6 mm× 200 mm ,5 μm) colmnn was used and methanol-acetonitrile-methanoic acid-water (30: 10: 1: 59) was as the mobile phase at flow rate of 1.0 mL . min^-1. The detection wavelength was 286 nm. Results:TCL results displayed that negative control was non-interference. The linear range of salvianolic acid B was 0. 054 67- 2. 186 69 ~g( r = 0. 999 9) , the main recovery (n = 6)was 99. 0%. Conclusion: The method is convenient, reliable and suitable for quality assessment of Shengshitong Pills .
Keywords:dehydrocostuslactone  Galli Gigerii Endothelium Corneum  kaempferol  quercetin  Lysimachiae Herba  salvianolic acid B  Shengshitong Pills  HPLC
本文献已被 CNKI 维普 万方数据 等数据库收录!
点击此处可从《中国药品标准》浏览原始摘要信息
点击此处可从《中国药品标准》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号