胎盘生长因子与急性冠脉综合征关系探讨

目的 探讨胎盘生长因子与急性冠脉综合征(ACS)的相关性.方法 临床上70例急性胸痛患者,肌钙蛋白阳性患者36例患者作为观察组,对照组34例肌钙蛋白阴性,所有患者入院即行血检验PLGF,住院过程中行冠脉造影检查,Gemini积分评估冠脉病变情况.结果 胎盘生长因子与肌钙蛋白在ACS中显著增高,与对照组比较有显著性差异(P<0.01),胎盘生长因子与肌钙蛋白呈正相关(r=1.2,P<0.01),胎盘生长因子与冠脉病变严重程度呈正相关(r=1,P<0.01).结论 胎盘生长因子在预测急性冠脉综合征有一定作用,较高血胎盘生长因子预示冠脉病变处于不稳定性.

Relationship between placental growth factor and acute coronary syndrome

Objecitve To investigate the relationship between placental growth factor and acute coronary syndrome(ACS). Methods 70 cases of patients with acute chest pain were enrolled. 36 cases of patients who is posi-tive on cardiac troponin T(cTnT) as treatment group, 24 patients who is negative on cTnT as control group, blood of all patients were detected about PLGF and cTnT in hospital,and coromary angiography examination, Gemini score is used to evaluate coronary artery lesion. Result PLGF and cTnT were elevated in ACS, it had significant difference between two groups(P <0. 01) ,PLGF and cTnT are significantly positive correlated(r= 1.2,P <0. 01), PLGF and cornorary artery lesion severity are significantly positive correlated(r = 1 ,P <0. 01). Conclusion PLGF is helpful to predict ACS attack to comorary heart disease,higher PLGF predicts unstable to coronary artery lesion in coronary heart disease.