抗焦虑药联合认知行为疗法对初诊高血压疗效的影响

目的 探讨抗焦虑治疗联合认知行为疗法对初诊高血压患者疗效的影响.方法 将60例初诊高血压患者随机分为A组（常规降压治疗＋抗焦虑治疗和认知行为疗法）及B组（常规降压治疗）,同时选择15例年龄、性别相匹配的健康人为C组.每组各观察8周,比较各组治疗后的降压效果、焦虑自评量表（SAS）评分变化及血浆血管性假性血友病因子（VWF）和血清高敏C-反应蛋白（hs-CRP）水平的变化.结果 初诊高血压患者存在明显的焦虑状态.抗焦虑治疗联合认知行为疗法后A组患者血压下降更明显,SAS评分平均减少显著低于B组（P〈0.01）,血浆VWF及血清hs-CRP水平均较B、C组显著降低（均P〈0.01）.结论 初诊高血压患者存在明显的焦虑状态.抗焦虑治疗联合认知行为疗法较常规降压治疗明显提高初诊高血压患者的降压效果,同时也明显地降低焦虑情绪及血浆VWF及血清hs-CRP水平.

Effect of Cognitive Behavioral Therapy combined Anti-anxiety drou On Preliminary Hypertension Patients

Objective To evaluate the curative effect of combined cognitive behaviioral therapy with alprazolam anti-anxiety. on patients with preliminary hypertemsion. Methods After evaluating by self-rating anxiety scale (SAS) ,60 outpatients with preliminary hypertension were randomly divided into A and B groups. The A group (n = 29) were accepted the combined cognitive behavioral therapy with alprazolam anti-anxiety for 8 weeks at the basis with medication, the B group ( n = 31 ) given rontine medication only. Meantimes, fifteen healthy volunteers who matched with age and sex were selected as the normal control group ( C group ). The blood pressure of all the subjects were recorded at the begin and after eight-weeks therapy,and the levels of plasma von willebrand factor (VWF) and serum high-sensitive reaction protein(hs-CRP) were measured respectively. The evaluating by self-rating anxiety scale (SAS) were performed in the A and B groups,before and after the treatment at the same time. Results The patients with preliminary hypertension have higher SAS score as well as the levels of plasma VWF and serum hs-CRP. After psychotherapy,in A group,the SAS score,the levels of VWF and serum hs-CRP, and the blood pressure were significantly decreased( P < 0. 01 ),compared with those in B group, however, were still significantly higher than those of C group( P < 0. 01 ). Conclusion The patients with preliminary hypertension showed some-degrees anxious emotion. By combined cognitive behavioral therapy with alprazolam anti-anxiety,we could not only more positively control the patients, blood pressure,but also improve the patients emotion states,as well as decrease the levels of VWF and hs-CRP.