中性粒细胞碱性磷酸酶活性测定对系统性红斑狼疮的诊断价值

目的 探讨中性粒细胞碱性磷酸酶在系统性红斑狼疮诊断中的价值.方法 采用AS-BI法对30例初诊的SLE患者(SLE组)及30例体检健康女性(对照组)外周血涂片进行NAP染色,观察NAP阳性率及阳性积分.结果 SLE患者阳性率、阳性积分分别为(22.1±8.8)%、(22.2±8.9)分;健康对照组阳性率、阳性积分分别为(56.8±9.4)%、(58.2±9.8)分,两者比较差异有统计学意义(P＜0.01).结论 NAP检测对初诊的SLE患者有一定的诊断价值;其在SLE中活性降低的机制尚待进一步探讨.

The diagnostic value of neutrophilic alkaline phosphatase activity detection in systemic lupus erythematosus

Objective To explore the diagnostic value of NAP activity detection in SLE.Methods Technique of AS-BI was used to NAP staining of peripheral blood smear in patients with newly-diagnosed SLE(30 cases)and normal healthy women(30 cases),to observe positive rate and positive score of NAP.Results The positive rate was(22.1±8.8)% in group SLE,(56.8±9.4)% in group normal;The positive score was(22.2±8.9)in group SLE,(58.2±9.8)in group normal.The positive rate and positive score were much lower in patients with SLE comparing with those in group normal.Differences were statistically significant(P＜0.01).Conclusions The detection of NAP is useful in the patients with newly-diagnosed SLE,but we must go on researching the pathogenesis of NAP activity decreased in SLE.