奥美拉唑、左氧氟沙星和甲硝唑联合治疗幽门螺杆菌所致慢性胃炎疗效观察

目的 探究奥美拉唑、左氧氟沙星和甲硝唑联合治疗幽门螺杆菌（Hp）所致慢性胃炎的临床疗效.方法 以100例慢性胃炎患者为研究对象,按照随机数字表法分为观察组和对照组,每组50例.观察组接受奥美拉唑、左氧氟沙星和甲硝唑三联法治疗,对照组只接受奥美拉唑治疗.结果 观察组总有效率（94％）显著高于对照组（82％）（x2=7.37,P＜0.05）.观察组Hp转阴率90％,对照组为72％,观察组抑制Hp效果优于对照组（x2 =8.12,P＜0.05）.结论 采用奥美拉唑、左氧氟沙星和甲硝唑治疗Hp优于单用奥美拉唑,疗效显著,不良反应少、安全.

Clinical observation of the effect of omeprazole,levofloxacin and metronidazole in the treatment of Helicobacter pylori induced chronic gastritis

Objective To explore the clinical efficacy of omeprazole,levofloxacin and metronidazole in the treatment of chronic gastritis caused by Helicobacter pylori.Methods 100 patients with chronic gastritis were selected as the research subjects.In accordance with digital table method,100 patients were randomly divided into the observation group and control group.Each group had 50 patients.The observation group was given triple therapy with omeprazole,levofloxacin and metronidasole.The control group was only given omeprazole.Results The total effective rate of the observation group was 94%,which was significantly higher than 82% of the control group （x2 =7.37,P 〈 0.05）.The negative rate of Hp in observation group was 90%,which was significantly higher than 72% of the control group （x2 =8.12,P 〈 0.05）.Conclusion The clinical efficacy of triple therapy of omeprazole,levofloxacin and metronidazole was better than the single therapy of omeprazole,which has significant effect,less adverse reactions.